Multiscale imaging of human thyroid pathologies using integrated Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM)
We evaluate the feasibility of optical coherence tomography (OCT) and optical coherence microscopy (OCM) for imaging of benign and malignant thyroid lesions ex vivo using intrinsic optical contrast. Thirty four thyroid gland specimens were imaged from 17 patients, covering a spectrum of pathology, r...
| Main Authors: | , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
SPIE
2010
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/1721.1/58587 https://orcid.org/0000-0002-0828-4357 |
| _version_ | 1811086051183165440 |
|---|---|
| author | Zhou, Chao Wong, Yihong Aguirre, Aaron Dominic Tsai, Tsung-Han Cohen, David W. Connolly, James L. Fujimoto, James G. |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Zhou, Chao Wong, Yihong Aguirre, Aaron Dominic Tsai, Tsung-Han Cohen, David W. Connolly, James L. Fujimoto, James G. |
| author_sort | Zhou, Chao |
| collection | MIT |
| description | We evaluate the feasibility of optical coherence tomography (OCT) and optical coherence microscopy (OCM) for imaging of benign and malignant thyroid lesions ex vivo using intrinsic optical contrast. Thirty four thyroid gland specimens were imaged from 17 patients, covering a spectrum of pathology, ranging from normal thyroid to neoplasia and benign disease. The integrated OCT and OCM imaging system allows seamlessly switching between low and high magnifications, in a way similar to traditional microscopy. Good correspondence was observed between optical images and histological sections. The results provide a basis for interpretation of future OCT and OCM images of the thyroid tissues and suggest the possibility of future in vivo evaluation of thyroid pathology. |
| first_indexed | 2024-09-23T13:20:07Z |
| format | Article |
| id | mit-1721.1/58587 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:20:07Z |
| publishDate | 2010 |
| publisher | SPIE |
| record_format | dspace |
| spelling | mit-1721.1/585872022-09-28T13:28:23Z Multiscale imaging of human thyroid pathologies using integrated Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM) Zhou, Chao Wong, Yihong Aguirre, Aaron Dominic Tsai, Tsung-Han Cohen, David W. Connolly, James L. Fujimoto, James G. Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Fujimoto, James G. Zhou, Chao Aguirre, Aaron Dominic Tsai, Tsung-Han Fujimoto, James G. Optical coherence tomography (OCT) Optical coherence microscopy (OCM) Thyroid Pathology Cancer We evaluate the feasibility of optical coherence tomography (OCT) and optical coherence microscopy (OCM) for imaging of benign and malignant thyroid lesions ex vivo using intrinsic optical contrast. Thirty four thyroid gland specimens were imaged from 17 patients, covering a spectrum of pathology, ranging from normal thyroid to neoplasia and benign disease. The integrated OCT and OCM imaging system allows seamlessly switching between low and high magnifications, in a way similar to traditional microscopy. Good correspondence was observed between optical images and histological sections. The results provide a basis for interpretation of future OCT and OCM images of the thyroid tissues and suggest the possibility of future in vivo evaluation of thyroid pathology. National Institutes of Health (U.S) ( R01-CA75289-13 ) United States. Air Force Office of Scientific Research (contract FA9550-07-1-0014) United States. Dept. of Defense.Medical Free Electron Laser Program (contract FA9550-07-1-0101) MIT/CIMIT Medical Engineering Fellowship 2010-09-17T17:28:04Z 2010-09-17T17:28:04Z 2010-02 2010-01 Article http://purl.org/eprint/type/JournalArticle 0277-786X http://hdl.handle.net/1721.1/58587 Zhou, Chao et al. “Multiscale imaging of human thyroid pathologies using integrated optical coherence tomography (OCT) and optical coherence microscopy (OCM).” Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV. Ed. Joseph A. Izatt, James G. Fujimoto, & Valery V. Tuchin. San Francisco, California, USA: SPIE, 2010. 755409-8. ©2010 COPYRIGHT SPIE--The International Society for Optical Engineering https://orcid.org/0000-0002-0828-4357 en_US http://dx.doi.org/10.1117/12.843616 Proceedings of SPIE--the International Society for Optical Engineering; v.7554 Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf SPIE SPIE |
| spellingShingle | Optical coherence tomography (OCT) Optical coherence microscopy (OCM) Thyroid Pathology Cancer Zhou, Chao Wong, Yihong Aguirre, Aaron Dominic Tsai, Tsung-Han Cohen, David W. Connolly, James L. Fujimoto, James G. Multiscale imaging of human thyroid pathologies using integrated Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM) |
| title | Multiscale imaging of human thyroid pathologies using integrated Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM) |
| title_full | Multiscale imaging of human thyroid pathologies using integrated Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM) |
| title_fullStr | Multiscale imaging of human thyroid pathologies using integrated Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM) |
| title_full_unstemmed | Multiscale imaging of human thyroid pathologies using integrated Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM) |
| title_short | Multiscale imaging of human thyroid pathologies using integrated Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM) |
| title_sort | multiscale imaging of human thyroid pathologies using integrated optical coherence tomography oct and optical coherence microscopy ocm |
| topic | Optical coherence tomography (OCT) Optical coherence microscopy (OCM) Thyroid Pathology Cancer |
| url | http://hdl.handle.net/1721.1/58587 https://orcid.org/0000-0002-0828-4357 |
| work_keys_str_mv | AT zhouchao multiscaleimagingofhumanthyroidpathologiesusingintegratedopticalcoherencetomographyoctandopticalcoherencemicroscopyocm AT wongyihong multiscaleimagingofhumanthyroidpathologiesusingintegratedopticalcoherencetomographyoctandopticalcoherencemicroscopyocm AT aguirreaarondominic multiscaleimagingofhumanthyroidpathologiesusingintegratedopticalcoherencetomographyoctandopticalcoherencemicroscopyocm AT tsaitsunghan multiscaleimagingofhumanthyroidpathologiesusingintegratedopticalcoherencetomographyoctandopticalcoherencemicroscopyocm AT cohendavidw multiscaleimagingofhumanthyroidpathologiesusingintegratedopticalcoherencetomographyoctandopticalcoherencemicroscopyocm AT connollyjamesl multiscaleimagingofhumanthyroidpathologiesusingintegratedopticalcoherencetomographyoctandopticalcoherencemicroscopyocm AT fujimotojamesg multiscaleimagingofhumanthyroidpathologiesusingintegratedopticalcoherencetomographyoctandopticalcoherencemicroscopyocm |