Hydrodynamics of cell-cell mechanical signaling in the initial stages of aggregation
Mechanotactic cell motility has recently been shown to be a key player in the initial aggregation of crawling cells such as leukocytes and amoebae. The effects of mechanotactic signaling in the early aggregation of amoeboid cells are here investigated using a general mathematical model based on know...
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| Format: | Article |
| Language: | en_US |
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American Physical Society
2010
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| Online Access: | http://hdl.handle.net/1721.1/58600 https://orcid.org/0000-0002-0141-2168 https://orcid.org/0000-0003-1273-9964 |
| _version_ | 1826201457190240256 |
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| author | Bouffanais, Roland Yue, Dick K. P. |
| author2 | Massachusetts Institute of Technology. Department of Mechanical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Mechanical Engineering Bouffanais, Roland Yue, Dick K. P. |
| author_sort | Bouffanais, Roland |
| collection | MIT |
| description | Mechanotactic cell motility has recently been shown to be a key player in the initial aggregation of crawling cells such as leukocytes and amoebae. The effects of mechanotactic signaling in the early aggregation of amoeboid cells are here investigated using a general mathematical model based on known biological evidence. We elucidate the hydrodynamic fundamentals of the direct guiding of a cell through mechanotaxis in the case where one cell transmits a mechanotactic signal through the fluid flow by changing its shape. It is found that any mechanosensing cells placed in the stimulus field of mechanical stress are able to determine the signal transmission direction with a certain angular dispersion which does not preclude the aggregation from happening. The ubiquitous presence of noise is accounted for by the model. Finally, the mesoscopic pattern of aggregation is obtained which constitutes the bridge between, on one hand, the microscopic world where the changes in the cell shape occur and, on the other hand, the cooperative behavior of the cells at the mesoscopic scale. |
| first_indexed | 2024-09-23T11:52:08Z |
| format | Article |
| id | mit-1721.1/58600 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:52:08Z |
| publishDate | 2010 |
| publisher | American Physical Society |
| record_format | dspace |
| spelling | mit-1721.1/586002022-09-27T22:29:27Z Hydrodynamics of cell-cell mechanical signaling in the initial stages of aggregation Bouffanais, Roland Yue, Dick K. P. Massachusetts Institute of Technology. Department of Mechanical Engineering Yue, Dick K. P. Bouffanais, Roland Yue, Dick K. P. Mechanotactic cell motility has recently been shown to be a key player in the initial aggregation of crawling cells such as leukocytes and amoebae. The effects of mechanotactic signaling in the early aggregation of amoeboid cells are here investigated using a general mathematical model based on known biological evidence. We elucidate the hydrodynamic fundamentals of the direct guiding of a cell through mechanotaxis in the case where one cell transmits a mechanotactic signal through the fluid flow by changing its shape. It is found that any mechanosensing cells placed in the stimulus field of mechanical stress are able to determine the signal transmission direction with a certain angular dispersion which does not preclude the aggregation from happening. The ubiquitous presence of noise is accounted for by the model. Finally, the mesoscopic pattern of aggregation is obtained which constitutes the bridge between, on one hand, the microscopic world where the changes in the cell shape occur and, on the other hand, the cooperative behavior of the cells at the mesoscopic scale. United States. Office of Naval Research Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) (PBELA-118718) 2010-09-20T18:12:51Z 2010-09-20T18:12:51Z 2010-04 2010-03 Article http://purl.org/eprint/type/JournalArticle 1539-3755 1550-2376 http://hdl.handle.net/1721.1/58600 Bouffanais, Roland, and Dick K.P. Yue. "Hydrodynamics of cell-cell mechanical signaling in the initial stages of aggregation." Physical Review E 81.4 (2010): 041920. © 2010 The American Physical Society. https://orcid.org/0000-0002-0141-2168 https://orcid.org/0000-0003-1273-9964 en_US http://dx.doi.org/10.1103/PhysRevE.81.041920 Physical Review E Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Physical Society APS |
| spellingShingle | Bouffanais, Roland Yue, Dick K. P. Hydrodynamics of cell-cell mechanical signaling in the initial stages of aggregation |
| title | Hydrodynamics of cell-cell mechanical signaling in the initial stages of aggregation |
| title_full | Hydrodynamics of cell-cell mechanical signaling in the initial stages of aggregation |
| title_fullStr | Hydrodynamics of cell-cell mechanical signaling in the initial stages of aggregation |
| title_full_unstemmed | Hydrodynamics of cell-cell mechanical signaling in the initial stages of aggregation |
| title_short | Hydrodynamics of cell-cell mechanical signaling in the initial stages of aggregation |
| title_sort | hydrodynamics of cell cell mechanical signaling in the initial stages of aggregation |
| url | http://hdl.handle.net/1721.1/58600 https://orcid.org/0000-0002-0141-2168 https://orcid.org/0000-0003-1273-9964 |
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