Probing nanoantenna-directed photothermal destruction of tumors using noninvasive laser irradiation
Plasmonic nanomaterials have tremendous potential to improve the tumor specificity of traditional cancer ablation practices, yet little effort has been directed toward quantitatively understanding their photothermal energy conversion in tumor tissues. In the present work, we develop a predictive mod...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | en_US |
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American Institute of Physics
2010
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| Online Access: | http://hdl.handle.net/1721.1/58698 https://orcid.org/0000-0002-1293-2097 |
| _version_ | 1826218022911606784 |
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| author | DasGupta, Debabrata von Maltzahn, Geoffrey Ghosh, Soham Bhatia, Sangeeta N. Das, Sarit K. Chakraborty, Suman |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology DasGupta, Debabrata von Maltzahn, Geoffrey Ghosh, Soham Bhatia, Sangeeta N. Das, Sarit K. Chakraborty, Suman |
| author_sort | DasGupta, Debabrata |
| collection | MIT |
| description | Plasmonic nanomaterials have tremendous potential to improve the tumor specificity of traditional cancer ablation practices, yet little effort has been directed toward quantitatively understanding their photothermal energy conversion in tumor tissues. In the present work, we develop a predictive model for plasmonic nanomaterial assisted tumor destruction under extracorporeal laser irradiation. Instead of appealing to heuristically based laser intensification models with tunable, tissue absorption and scattering coefficients, we consider fundamental characteristics of optoelectrothermal energy conversion and heat dissipation for plasmonic nanomaterials within living tumor tissues to construct a simulation tool that accurately reproduces our experimental findings, including aspects of delayed time-temperature characteristics. We believe the comprehensive modeling strategy outlined here provides a groundwork for the development of anticipatory therapeutic planning tools with individually tailored treatment plans, resulting in an ultimate benefit to ailing cancer patients. |
| first_indexed | 2024-09-23T17:12:56Z |
| format | Article |
| id | mit-1721.1/58698 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T17:12:56Z |
| publishDate | 2010 |
| publisher | American Institute of Physics |
| record_format | dspace |
| spelling | mit-1721.1/586982022-10-03T11:10:03Z Probing nanoantenna-directed photothermal destruction of tumors using noninvasive laser irradiation DasGupta, Debabrata von Maltzahn, Geoffrey Ghosh, Soham Bhatia, Sangeeta N. Das, Sarit K. Chakraborty, Suman Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Bhatia, Sangeeta N. von Maltzahn, Geoffrey Bhatia, Sangeeta N. Plasmonic nanomaterials have tremendous potential to improve the tumor specificity of traditional cancer ablation practices, yet little effort has been directed toward quantitatively understanding their photothermal energy conversion in tumor tissues. In the present work, we develop a predictive model for plasmonic nanomaterial assisted tumor destruction under extracorporeal laser irradiation. Instead of appealing to heuristically based laser intensification models with tunable, tissue absorption and scattering coefficients, we consider fundamental characteristics of optoelectrothermal energy conversion and heat dissipation for plasmonic nanomaterials within living tumor tissues to construct a simulation tool that accurately reproduces our experimental findings, including aspects of delayed time-temperature characteristics. We believe the comprehensive modeling strategy outlined here provides a groundwork for the development of anticipatory therapeutic planning tools with individually tailored treatment plans, resulting in an ultimate benefit to ailing cancer patients. DST of the Government of India 2010-09-24T14:16:45Z 2010-09-24T14:16:45Z 2009-12 2009-10 Article http://purl.org/eprint/type/JournalArticle 1077-3118 0003-6951 http://hdl.handle.net/1721.1/58698 DasGupta, Debabrata et al. “Probing nanoantenna-directed photothermal destruction of tumors using noninvasive laser irradiation.” Applied Physics Letters 95.23 (2009): 233701-3. © 2009 American Institute of Physics. https://orcid.org/0000-0002-1293-2097 en_US http://dx.doi.org/10.1063/1.3271522 Applied Physical Letters Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Institute of Physics MIT Web Domain |
| spellingShingle | DasGupta, Debabrata von Maltzahn, Geoffrey Ghosh, Soham Bhatia, Sangeeta N. Das, Sarit K. Chakraborty, Suman Probing nanoantenna-directed photothermal destruction of tumors using noninvasive laser irradiation |
| title | Probing nanoantenna-directed photothermal destruction of tumors using noninvasive laser irradiation |
| title_full | Probing nanoantenna-directed photothermal destruction of tumors using noninvasive laser irradiation |
| title_fullStr | Probing nanoantenna-directed photothermal destruction of tumors using noninvasive laser irradiation |
| title_full_unstemmed | Probing nanoantenna-directed photothermal destruction of tumors using noninvasive laser irradiation |
| title_short | Probing nanoantenna-directed photothermal destruction of tumors using noninvasive laser irradiation |
| title_sort | probing nanoantenna directed photothermal destruction of tumors using noninvasive laser irradiation |
| url | http://hdl.handle.net/1721.1/58698 https://orcid.org/0000-0002-1293-2097 |
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