High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery
This study demonstrates the first real-time imaging in vivo of human cartilage in normal and osteoarthritic knee joints at a resolution of micrometers, using optical coherence tomography (OCT). This recently developed high-resolution imaging technology is analogous to B-mode ultrasound except that i...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BioMed Central Ltd
2010
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| Online Access: | http://hdl.handle.net/1721.1/58852 https://orcid.org/0000-0002-0828-4357 |
| _version_ | 1811070539215667200 |
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| author | Harman, Michelle Li, Xingde Pitris, Costas Ghanta, Ravi Fujimoto, James G. Stamper, Debra L. Brezinski, Mark E. Martin, Scott |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Harman, Michelle Li, Xingde Pitris, Costas Ghanta, Ravi Fujimoto, James G. Stamper, Debra L. Brezinski, Mark E. Martin, Scott |
| author_sort | Harman, Michelle |
| collection | MIT |
| description | This study demonstrates the first real-time imaging in vivo of human cartilage in normal and osteoarthritic knee joints at a resolution of micrometers, using optical coherence tomography (OCT). This recently developed high-resolution imaging technology is analogous to B-mode ultrasound except that it uses infrared light rather than sound. Real-time imaging with 11-μm resolution at four frames per second was performed on six patients using a portable OCT system with a handheld imaging probe during open knee surgery. Tissue registration was achieved by marking sites before imaging, and then histologic processing was performed. Structural changes including cartilage thinning, fissures, and fibrillations were observed at a resolution substantially higher than is achieved with any current clinical imaging technology. The structural features detected with OCT were evident in the corresponding histology. In addition to changes in architectural morphology, changes in the birefringent or the polarization properties of the articular cartilage were observed with OCT, suggesting collagen disorganization, an early indicator of osteoarthritis. Furthermore, this study supports the hypothesis that polarization-sensitive OCT may allow osteoarthritis to be diagnosed before cartilage thinning. This study illustrates that OCT, which can eventually be developed for use in offices or through an arthroscope, has considerable potential for assessing early osteoarthritic cartilage and monitoring therapeutic effects for cartilage repair with resolution in real time on a scale of micrometers. |
| first_indexed | 2024-09-23T08:37:38Z |
| format | Article |
| id | mit-1721.1/58852 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:37:38Z |
| publishDate | 2010 |
| publisher | BioMed Central Ltd |
| record_format | dspace |
| spelling | mit-1721.1/588522022-09-30T10:04:28Z High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery Harman, Michelle Li, Xingde Pitris, Costas Ghanta, Ravi Fujimoto, James G. Stamper, Debra L. Brezinski, Mark E. Martin, Scott Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Li, Xingde Pitris, Costas Ghanta, Ravi Fujimoto, James G. This study demonstrates the first real-time imaging in vivo of human cartilage in normal and osteoarthritic knee joints at a resolution of micrometers, using optical coherence tomography (OCT). This recently developed high-resolution imaging technology is analogous to B-mode ultrasound except that it uses infrared light rather than sound. Real-time imaging with 11-μm resolution at four frames per second was performed on six patients using a portable OCT system with a handheld imaging probe during open knee surgery. Tissue registration was achieved by marking sites before imaging, and then histologic processing was performed. Structural changes including cartilage thinning, fissures, and fibrillations were observed at a resolution substantially higher than is achieved with any current clinical imaging technology. The structural features detected with OCT were evident in the corresponding histology. In addition to changes in architectural morphology, changes in the birefringent or the polarization properties of the articular cartilage were observed with OCT, suggesting collagen disorganization, an early indicator of osteoarthritis. Furthermore, this study supports the hypothesis that polarization-sensitive OCT may allow osteoarthritis to be diagnosed before cartilage thinning. This study illustrates that OCT, which can eventually be developed for use in offices or through an arthroscope, has considerable potential for assessing early osteoarthritic cartilage and monitoring therapeutic effects for cartilage repair with resolution in real time on a scale of micrometers. National Institutes of Health (U.S.) (Contract R01-AR44812) (Contract R01-EB000419) (Contract R01 AR46996) (Contract R01-HL55686) (Contract R01-EB002638) (Contract NIH-RO1-HL63953) (Contract NIH-1-R29-HL55686) (Contract NIH- 9-RO1-EY11289) (Contract NIH-1-RO1-CA75289) Medical Free Electron Laser Program United States. Office of Naval Research (Contract grant N00014-97-1-1066) Whitaker Foundation (Contract 96-0205) 2010-10-04T19:23:07Z 2010-10-04T19:23:07Z 2005-01 2004-11 2010-09-03T16:19:12Z Article http://purl.org/eprint/type/JournalArticle 1478-6362 1478-6354 http://hdl.handle.net/1721.1/58852 Arthritis Research & Therapy. 2005 Jan 17;7(2):R318-R323 15743479 https://orcid.org/0000-0002-0828-4357 en http://dx.doi.org/10.1186/ar1491 Arthritis Research and Therapy Creative Commons Attribution http://creativecommons.org/licenses/by/2.0 Li, PhD et al.; licensee BioMed Central Ltd. application/pdf BioMed Central Ltd BioMed Central Ltd |
| spellingShingle | Harman, Michelle Li, Xingde Pitris, Costas Ghanta, Ravi Fujimoto, James G. Stamper, Debra L. Brezinski, Mark E. Martin, Scott High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery |
| title | High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery |
| title_full | High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery |
| title_fullStr | High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery |
| title_full_unstemmed | High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery |
| title_short | High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery |
| title_sort | high resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery |
| url | http://hdl.handle.net/1721.1/58852 https://orcid.org/0000-0002-0828-4357 |
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