Computer-Aided Design for Microfluidic Chips Based on Multilayer Soft Lithography
Microfluidic chips are emerging as a powerful platform for automating biology experiments. As it becomes possible to integrate tens of thousands of components on a single chip, researchers will require design automation tools to push the scale and complexity of their designs to match the capabilitie...
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Institute of Electrical and Electronics Engineers
2010
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| Online Access: | http://hdl.handle.net/1721.1/58877 https://orcid.org/0000-0002-7231-7643 |
| _version_ | 1826197892685103104 |
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| author | Amarasinghe, Saman P. Amin, Nada Thies, William |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Amarasinghe, Saman P. Amin, Nada Thies, William |
| author_sort | Amarasinghe, Saman P. |
| collection | MIT |
| description | Microfluidic chips are emerging as a powerful platform for automating biology experiments. As it becomes possible to integrate tens of thousands of components on a single chip, researchers will require design automation tools to push the scale and complexity of their designs to match the capabilities of the substrate. However, to date such tools have focused only on droplet-based devices, leaving out the popular class of chips that are based on multilayer soft lithography.
In this paper, we develop design automation techniques for microfluidic chips based on multilayer soft lithography. We focus our attention on the control layer, which is driven by pressure actuators to invoke the desired flows on chip. We present a language in which designers can specify the Instruction Set Architecture (ISA) of a microfluidic device. Given an ISA, we automatically infer the locations of valves needed to implement the ISA. We also present novel algorithms for minimizing the number of control lines needed to drive the valves, as well as for routing valves to control ports while admitting sharing between the control lines.
To the microfluidic community, we offer a free computer-aided design tool, Micado, which implements a subset of our algorithms as a practical plug-in to AutoCAD. Micado is being used successfully by microfluidic designers. We demonstrate its performance on three realistic chips. |
| first_indexed | 2024-09-23T10:55:34Z |
| format | Article |
| id | mit-1721.1/58877 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:55:34Z |
| publishDate | 2010 |
| publisher | Institute of Electrical and Electronics Engineers |
| record_format | dspace |
| spelling | mit-1721.1/588772022-09-30T23:56:46Z Computer-Aided Design for Microfluidic Chips Based on Multilayer Soft Lithography Amarasinghe, Saman P. Amin, Nada Thies, William Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Amarasinghe, Saman P. Amarasinghe, Saman P. Amin, Nada Microfluidic chips are emerging as a powerful platform for automating biology experiments. As it becomes possible to integrate tens of thousands of components on a single chip, researchers will require design automation tools to push the scale and complexity of their designs to match the capabilities of the substrate. However, to date such tools have focused only on droplet-based devices, leaving out the popular class of chips that are based on multilayer soft lithography. In this paper, we develop design automation techniques for microfluidic chips based on multilayer soft lithography. We focus our attention on the control layer, which is driven by pressure actuators to invoke the desired flows on chip. We present a language in which designers can specify the Instruction Set Architecture (ISA) of a microfluidic device. Given an ISA, we automatically infer the locations of valves needed to implement the ISA. We also present novel algorithms for minimizing the number of control lines needed to drive the valves, as well as for routing valves to control ports while admitting sharing between the control lines. To the microfluidic community, we offer a free computer-aided design tool, Micado, which implements a subset of our algorithms as a practical plug-in to AutoCAD. Micado is being used successfully by microfluidic designers. We demonstrate its performance on three realistic chips. National Science Foundation (U.S.) (# CCF-0541319) 2010-10-05T19:37:24Z 2010-10-05T19:37:24Z 2009-01 Article http://purl.org/eprint/type/JournalArticle 978-1-4244-5029-9 1063-6404 http://hdl.handle.net/1721.1/58877 Amin, Nada, William Thies, and Saman Amarasinghe. “Computer-aided design for microfluidic chips based on multilayer soft lithography.” Proceedings of the 2009 IEEE International Conference on Computer design. Lake Tahoe, California, USA: IEEE Press, 2009. 2-9. ©2009 Institute of Electrical and Electronics Engineers. https://orcid.org/0000-0002-7231-7643 en_US Proceedings of the 2009 IEEE International Conference on Computer design Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Institute of Electrical and Electronics Engineers IEEE |
| spellingShingle | Amarasinghe, Saman P. Amin, Nada Thies, William Computer-Aided Design for Microfluidic Chips Based on Multilayer Soft Lithography |
| title | Computer-Aided Design for Microfluidic Chips Based on Multilayer Soft Lithography |
| title_full | Computer-Aided Design for Microfluidic Chips Based on Multilayer Soft Lithography |
| title_fullStr | Computer-Aided Design for Microfluidic Chips Based on Multilayer Soft Lithography |
| title_full_unstemmed | Computer-Aided Design for Microfluidic Chips Based on Multilayer Soft Lithography |
| title_short | Computer-Aided Design for Microfluidic Chips Based on Multilayer Soft Lithography |
| title_sort | computer aided design for microfluidic chips based on multilayer soft lithography |
| url | http://hdl.handle.net/1721.1/58877 https://orcid.org/0000-0002-7231-7643 |
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