Validation and refinement of gene-regulatory pathways on a network of physical interactions
As genome-scale measurements lead to increasingly complex models of gene regulation, systematic approaches are needed to validate and refine these models. Towards this goal, we describe an automated procedure for prioritizing genetic perturbations in order to discriminate optimally between alternati...
Main Authors: | Yeang, Chen-Hsiang, 1969-, Mak, Craig, McCuine, Scott, Workman, Christopher, Ideker, Trey, Jaakkola, Tommi S. |
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Other Authors: | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory |
Format: | Article |
Language: | English |
Published: |
BioMed Central Ltd
2010
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Online Access: | http://hdl.handle.net/1721.1/58915 https://orcid.org/0000-0002-2199-0379 |
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