A mouse plasma peptide atlas as a resource for disease proteomics
We present an in-depth analysis of mouse plasma leading to the development of a publicly available repository composed of 568 liquid chromatography-tandem mass spectrometry runs. A total of 13,779 distinct peptides have been identified with high confidence. The corresponding approximately 3,000 prot...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BioMed Central Ltd
2010
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| Online Access: | http://hdl.handle.net/1721.1/59306 https://orcid.org/0000-0001-5785-8911 |
| _version_ | 1826215965199695872 |
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| author | Zhang, Qing Menon, Rajasree Wang, Hong Bardeesy, Nabeel Dinulescu, Daniela M. Kucherlapati, Raju Politi, Katerina Aebersold, Ruedi Deutsch, Eric W. Pitteri, Sharon J. Faca, Vitor M. Newcomb, Lisa F. DePinho, Ronald A. Hung, Kenneth E. Omenn, Gilbert S. States, David J. Hanash, Samir M. Jacks, Tyler E |
| author2 | Koch Institute for Integrative Cancer Research at MIT |
| author_facet | Koch Institute for Integrative Cancer Research at MIT Zhang, Qing Menon, Rajasree Wang, Hong Bardeesy, Nabeel Dinulescu, Daniela M. Kucherlapati, Raju Politi, Katerina Aebersold, Ruedi Deutsch, Eric W. Pitteri, Sharon J. Faca, Vitor M. Newcomb, Lisa F. DePinho, Ronald A. Hung, Kenneth E. Omenn, Gilbert S. States, David J. Hanash, Samir M. Jacks, Tyler E |
| author_sort | Zhang, Qing |
| collection | MIT |
| description | We present an in-depth analysis of mouse plasma leading to the development of a publicly available repository composed of 568 liquid chromatography-tandem mass spectrometry runs. A total of 13,779 distinct peptides have been identified with high confidence. The corresponding approximately 3,000 proteins are estimated to span a 7 logarithmic range of abundance in plasma. A major finding from this study is the identification of novel isoforms and transcript variants not previously predicted from genome analysis. |
| first_indexed | 2024-09-23T16:40:15Z |
| format | Article |
| id | mit-1721.1/59306 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:40:15Z |
| publishDate | 2010 |
| publisher | BioMed Central Ltd |
| record_format | dspace |
| spelling | mit-1721.1/593062022-09-29T20:39:34Z A mouse plasma peptide atlas as a resource for disease proteomics Zhang, Qing Menon, Rajasree Wang, Hong Bardeesy, Nabeel Dinulescu, Daniela M. Kucherlapati, Raju Politi, Katerina Aebersold, Ruedi Deutsch, Eric W. Pitteri, Sharon J. Faca, Vitor M. Newcomb, Lisa F. DePinho, Ronald A. Hung, Kenneth E. Omenn, Gilbert S. States, David J. Hanash, Samir M. Jacks, Tyler E Koch Institute for Integrative Cancer Research at MIT Jacks, Tyler E. Alternative splicing Animals Databases, protein Humans Mice Peptides, analysis Plasma, chemistry Protein isoforms Proteomics Tandem mass spectrometry We present an in-depth analysis of mouse plasma leading to the development of a publicly available repository composed of 568 liquid chromatography-tandem mass spectrometry runs. A total of 13,779 distinct peptides have been identified with high confidence. The corresponding approximately 3,000 proteins are estimated to span a 7 logarithmic range of abundance in plasma. A major finding from this study is the identification of novel isoforms and transcript variants not previously predicted from genome analysis. National Heart, Lung, and Blood Institute (contract no. N01-HV-28179) National Cancer Institute (U.S.) 2010-10-14T12:22:33Z 2010-10-14T12:22:33Z 2008-06 2008-01 2010-09-03T16:07:07Z Article http://purl.org/eprint/type/JournalArticle 1474-760X 1465-6914 http://hdl.handle.net/1721.1/59306 Zhang, Qing et al. (2008). A mouse plasma peptide atlas as a resource for disease proteomics. Genome biology 9:R93/1-10. 18522751 https://orcid.org/0000-0001-5785-8911 en http://dx.doi.org/10.1186/gb-2008-9-6-r93 Genome Biology Creative Commons Attribution http://creativecommons.org/licenses/by/2.0 Zhang et al.; licensee BioMed Central Ltd. application/pdf BioMed Central Ltd BioMed Central Ltd |
| spellingShingle | Alternative splicing Animals Databases, protein Humans Mice Peptides, analysis Plasma, chemistry Protein isoforms Proteomics Tandem mass spectrometry Zhang, Qing Menon, Rajasree Wang, Hong Bardeesy, Nabeel Dinulescu, Daniela M. Kucherlapati, Raju Politi, Katerina Aebersold, Ruedi Deutsch, Eric W. Pitteri, Sharon J. Faca, Vitor M. Newcomb, Lisa F. DePinho, Ronald A. Hung, Kenneth E. Omenn, Gilbert S. States, David J. Hanash, Samir M. Jacks, Tyler E A mouse plasma peptide atlas as a resource for disease proteomics |
| title | A mouse plasma peptide atlas as a resource for disease proteomics |
| title_full | A mouse plasma peptide atlas as a resource for disease proteomics |
| title_fullStr | A mouse plasma peptide atlas as a resource for disease proteomics |
| title_full_unstemmed | A mouse plasma peptide atlas as a resource for disease proteomics |
| title_short | A mouse plasma peptide atlas as a resource for disease proteomics |
| title_sort | mouse plasma peptide atlas as a resource for disease proteomics |
| topic | Alternative splicing Animals Databases, protein Humans Mice Peptides, analysis Plasma, chemistry Protein isoforms Proteomics Tandem mass spectrometry |
| url | http://hdl.handle.net/1721.1/59306 https://orcid.org/0000-0001-5785-8911 |
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