Fabrication methods and performance of low-permeability microfluidic components for a miniaturized wearable drug delivery system

In this paper, we describe low-permeability components of a microfluidic drug delivery system fabricated with versatile micromilling and lamination techniques. The fabrication process uses laminate sheets which are machined using XY milling tables commonly used in the printed-circuit industry. This...

Ամբողջական նկարագրություն

Մատենագիտական մանրամասներ
Հիմնական հեղինակներ: Mescher, Mark J., Swan, Erin Leary, Fiering, Jason, Holmboe, Maria E., Sewell, William F., Kujawa, Sharon G., McKenna, Michael J., Borenstein, Jeffrey T.
Այլ հեղինակներ: Massachusetts Institute of Technology. Department of Mechanical Engineering
Ձևաչափ: Հոդված
Լեզու:en_US
Հրապարակվել է: Institute of Electrical and Electronics Engineers 2010
Առցանց հասանելիություն:http://hdl.handle.net/1721.1/59852
Նկարագրություն
Ամփոփում:In this paper, we describe low-permeability components of a microfluidic drug delivery system fabricated with versatile micromilling and lamination techniques. The fabrication process uses laminate sheets which are machined using XY milling tables commonly used in the printed-circuit industry. This adaptable platform for polymer microfluidics readily accommodates integration with silicon-based sensors, printed-circuit, and surface-mount technologies. We have used these methods to build components used in a wearable liquid-drug delivery system for in vivo studies. The design, fabrication, and performance of membrane-based fluidic capacitors and manual screw valves provide detailed examples of the capability and limitations of the fabrication method. We demonstrate fluidic capacitances ranging from 0.015 to 0.15 muL/kPa, screw valves with on/off flow ratios greater than 38000, and a 45times reduction in the aqueous fluid loss rate to the ambient due to permeation through a silicone diaphragm layer.