Fabrication methods and performance of low-permeability microfluidic components for a miniaturized wearable drug delivery system
In this paper, we describe low-permeability components of a microfluidic drug delivery system fabricated with versatile micromilling and lamination techniques. The fabrication process uses laminate sheets which are machined using XY milling tables commonly used in the printed-circuit industry. This...
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| Format: | Article |
| Language: | en_US |
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Institute of Electrical and Electronics Engineers
2010
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| Online Access: | http://hdl.handle.net/1721.1/59852 |
| _version_ | 1826195804170223616 |
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| author | Mescher, Mark J. Swan, Erin Leary Fiering, Jason Holmboe, Maria E. Sewell, William F. Kujawa, Sharon G. McKenna, Michael J. Borenstein, Jeffrey T. |
| author2 | Massachusetts Institute of Technology. Department of Mechanical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Mechanical Engineering Mescher, Mark J. Swan, Erin Leary Fiering, Jason Holmboe, Maria E. Sewell, William F. Kujawa, Sharon G. McKenna, Michael J. Borenstein, Jeffrey T. |
| author_sort | Mescher, Mark J. |
| collection | MIT |
| description | In this paper, we describe low-permeability components of a microfluidic drug delivery system fabricated with versatile micromilling and lamination techniques. The fabrication process uses laminate sheets which are machined using XY milling tables commonly used in the printed-circuit industry. This adaptable platform for polymer microfluidics readily accommodates integration with silicon-based sensors, printed-circuit, and surface-mount technologies. We have used these methods to build components used in a wearable liquid-drug delivery system for in vivo studies. The design, fabrication, and performance of membrane-based fluidic capacitors and manual screw valves provide detailed examples of the capability and limitations of the fabrication method. We demonstrate fluidic capacitances ranging from 0.015 to 0.15 muL/kPa, screw valves with on/off flow ratios greater than 38000, and a 45times reduction in the aqueous fluid loss rate to the ambient due to permeation through a silicone diaphragm layer. |
| first_indexed | 2024-09-23T10:15:43Z |
| format | Article |
| id | mit-1721.1/59852 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:15:43Z |
| publishDate | 2010 |
| publisher | Institute of Electrical and Electronics Engineers |
| record_format | dspace |
| spelling | mit-1721.1/598522022-09-26T16:47:56Z Fabrication methods and performance of low-permeability microfluidic components for a miniaturized wearable drug delivery system Mescher, Mark J. Swan, Erin Leary Fiering, Jason Holmboe, Maria E. Sewell, William F. Kujawa, Sharon G. McKenna, Michael J. Borenstein, Jeffrey T. Massachusetts Institute of Technology. Department of Mechanical Engineering McKenna, Michael J. Swan, Erin Leary In this paper, we describe low-permeability components of a microfluidic drug delivery system fabricated with versatile micromilling and lamination techniques. The fabrication process uses laminate sheets which are machined using XY milling tables commonly used in the printed-circuit industry. This adaptable platform for polymer microfluidics readily accommodates integration with silicon-based sensors, printed-circuit, and surface-mount technologies. We have used these methods to build components used in a wearable liquid-drug delivery system for in vivo studies. The design, fabrication, and performance of membrane-based fluidic capacitors and manual screw valves provide detailed examples of the capability and limitations of the fabrication method. We demonstrate fluidic capacitances ranging from 0.015 to 0.15 muL/kPa, screw valves with on/off flow ratios greater than 38000, and a 45times reduction in the aqueous fluid loss rate to the ambient due to permeation through a silicone diaphragm layer. National Institute of Deafness and other Communication Disorders (U.S.) (NIDCD) (Grant 5 R01 DC 006848-02) 2010-11-08T14:09:12Z 2010-11-08T14:09:12Z 2009-06 2008-10 Article http://purl.org/eprint/type/JournalArticle 1057-7157 INSPEC Accession Number: 10712724 http://hdl.handle.net/1721.1/59852 Mescher, M.J. et al. “Fabrication Methods and Performance of Low-Permeability Microfluidic Components for a Miniaturized Wearable Drug Delivery System.” Microelectromechanical Systems, Journal of 18.3 (2009): 501-510. © Copyright 2010 IEEE en_US http://dx.doi.org/10.1109/JMEMS.2009.2015484 Journal of Microelectromechanical Systems Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Institute of Electrical and Electronics Engineers IEEE |
| spellingShingle | Mescher, Mark J. Swan, Erin Leary Fiering, Jason Holmboe, Maria E. Sewell, William F. Kujawa, Sharon G. McKenna, Michael J. Borenstein, Jeffrey T. Fabrication methods and performance of low-permeability microfluidic components for a miniaturized wearable drug delivery system |
| title | Fabrication methods and performance of low-permeability microfluidic components for a miniaturized wearable drug delivery system |
| title_full | Fabrication methods and performance of low-permeability microfluidic components for a miniaturized wearable drug delivery system |
| title_fullStr | Fabrication methods and performance of low-permeability microfluidic components for a miniaturized wearable drug delivery system |
| title_full_unstemmed | Fabrication methods and performance of low-permeability microfluidic components for a miniaturized wearable drug delivery system |
| title_short | Fabrication methods and performance of low-permeability microfluidic components for a miniaturized wearable drug delivery system |
| title_sort | fabrication methods and performance of low permeability microfluidic components for a miniaturized wearable drug delivery system |
| url | http://hdl.handle.net/1721.1/59852 |
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