Log-domain circuit models of chemical reactions
We exploit the detailed similarities between electronics and chemistry to develop efficient, scalable bipolar or subthreshold log-domain circuits that are dynamically equivalent to networks of chemical reactions. Our circuits can be used for transient and steady-state simulations, parameter estimati...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Institute of Electrical and Electronics Engineers
2010
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| Online Access: | http://hdl.handle.net/1721.1/59983 https://orcid.org/0000-0003-0384-3786 |
| _version_ | 1826191917052854272 |
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| author | Mandal, Soumyajit Sarpeshkar, Rahul |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Mandal, Soumyajit Sarpeshkar, Rahul |
| author_sort | Mandal, Soumyajit |
| collection | MIT |
| description | We exploit the detailed similarities between electronics and chemistry to develop efficient, scalable bipolar or subthreshold log-domain circuits that are dynamically equivalent to networks of chemical reactions. Our circuits can be used for transient and steady-state simulations, parameter estimations and sensitivity analyses of large-scale biochemical networks. They allow the topology, rate constants, inputs, outputs and initial conditions of the reaction network to be programmed. When reactants are present in low concentrations, random fluctuations in reaction rates become significant; we can also model such stochastic effects. We present experimental results from a proof-of-concept chip implemented in 0.18 mum CMOS technology. |
| first_indexed | 2024-09-23T09:03:18Z |
| format | Article |
| id | mit-1721.1/59983 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:03:18Z |
| publishDate | 2010 |
| publisher | Institute of Electrical and Electronics Engineers |
| record_format | dspace |
| spelling | mit-1721.1/599832022-09-26T10:07:23Z Log-domain circuit models of chemical reactions Mandal, Soumyajit Sarpeshkar, Rahul Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Sarpeshkar, Rahul Mandal, Soumyajit Sarpeshkar, Rahul We exploit the detailed similarities between electronics and chemistry to develop efficient, scalable bipolar or subthreshold log-domain circuits that are dynamically equivalent to networks of chemical reactions. Our circuits can be used for transient and steady-state simulations, parameter estimations and sensitivity analyses of large-scale biochemical networks. They allow the topology, rate constants, inputs, outputs and initial conditions of the reaction network to be programmed. When reactants are present in low concentrations, random fluctuations in reaction rates become significant; we can also model such stochastic effects. We present experimental results from a proof-of-concept chip implemented in 0.18 mum CMOS technology. Massachusetts Institute of Technology. Poitras Pre-Doctoral Fellowship 2010-11-12T20:28:23Z 2010-11-12T20:28:23Z 2009-06 2009-05 Article http://purl.org/eprint/type/ConferencePaper 978-1-4244-3827-3 INSPEC Accession Number: 10760474 http://hdl.handle.net/1721.1/59983 Mandal, S., and R. Sarpeshkar. “Log-domain circuit models of chemical reactions.” Circuits and Systems, 2009. ISCAS 2009. IEEE International Symposium on. 2009. 2697-2700. ©2009 IEEE. https://orcid.org/0000-0003-0384-3786 en_US http://dx.doi.org/10.1109/ISCAS.2009.5118358 IEEE International Symposium on Circuits and Systems, 2009. ISCAS 2009 Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Institute of Electrical and Electronics Engineers IEEE |
| spellingShingle | Mandal, Soumyajit Sarpeshkar, Rahul Log-domain circuit models of chemical reactions |
| title | Log-domain circuit models of chemical reactions |
| title_full | Log-domain circuit models of chemical reactions |
| title_fullStr | Log-domain circuit models of chemical reactions |
| title_full_unstemmed | Log-domain circuit models of chemical reactions |
| title_short | Log-domain circuit models of chemical reactions |
| title_sort | log domain circuit models of chemical reactions |
| url | http://hdl.handle.net/1721.1/59983 https://orcid.org/0000-0003-0384-3786 |
| work_keys_str_mv | AT mandalsoumyajit logdomaincircuitmodelsofchemicalreactions AT sarpeshkarrahul logdomaincircuitmodelsofchemicalreactions |