Rapid Association Learning in the Primate Prefrontal Cortex in the Behavioral Reversals
The pFC plays a central role in our ability to learn arbitrary rules, such as “green means go.” Previous experiments from our laboratory have used conditional association learning to show that slow, gradual changes in pFC neural activity mirror monkeys' slow acquisition of associations. These p...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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MIT Press
2010
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| Online Access: | http://hdl.handle.net/1721.1/60320 |
| _version_ | 1826215549767516160 |
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| author | Cromer, Jason Machon, Michelle Miller, Earl K. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Cromer, Jason Machon, Michelle Miller, Earl K. |
| author_sort | Cromer, Jason |
| collection | MIT |
| description | The pFC plays a central role in our ability to learn arbitrary rules, such as “green means go.” Previous experiments from our laboratory have used conditional association learning to show that slow, gradual changes in pFC neural activity mirror monkeys' slow acquisition of associations. These previous experiments required monkeys to repeatedly reverse the cue–saccade associations, an ability known to be pFC dependent. We aimed to test whether the relationship between pFC neural activity and behavior was due to the reversal requirement, so monkeys were trained to learn several new conditional cue–saccade associations without reversing them. Learning-related changes in pFC activity now appeared earlier and more suddenly in correspondence with similar changes in behavioral improvement. This suggests that learning of conditional associations is linked to pFC activity regardless of whether reversals are required. However, when previous learning does not need to be suppressed, pFC acquires associations more rapidly. |
| first_indexed | 2024-09-23T16:34:39Z |
| format | Article |
| id | mit-1721.1/60320 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:34:39Z |
| publishDate | 2010 |
| publisher | MIT Press |
| record_format | dspace |
| spelling | mit-1721.1/603202022-10-02T08:18:33Z Rapid Association Learning in the Primate Prefrontal Cortex in the Behavioral Reversals Cromer, Jason Machon, Michelle Miller, Earl K. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Cromer, Jason Cromer, Jason Machon, Michelle Miller, Earl K. The pFC plays a central role in our ability to learn arbitrary rules, such as “green means go.” Previous experiments from our laboratory have used conditional association learning to show that slow, gradual changes in pFC neural activity mirror monkeys' slow acquisition of associations. These previous experiments required monkeys to repeatedly reverse the cue–saccade associations, an ability known to be pFC dependent. We aimed to test whether the relationship between pFC neural activity and behavior was due to the reversal requirement, so monkeys were trained to learn several new conditional cue–saccade associations without reversing them. Learning-related changes in pFC activity now appeared earlier and more suddenly in correspondence with similar changes in behavioral improvement. This suggests that learning of conditional associations is linked to pFC activity regardless of whether reversals are required. However, when previous learning does not need to be suppressed, pFC acquires associations more rapidly. National Institute of Neurological Disorders and Stroke (U.S.) (Grant no.5R29NS035145-04) 2010-12-17T22:10:03Z 2010-12-17T22:10:03Z 2010-07 Article http://purl.org/eprint/type/JournalArticle 0898-929X 1530-8898 http://hdl.handle.net/1721.1/60320 Cromer, Jason A, Michelle Machon, and Earl K Miller. “Rapid Association Learning in the Primate Prefrontal Cortex in the Absence of Behavioral Reversals.” Journal of Cognitive Neuroscience 0.0: 1-6. © 2010 The MIT Press en_US http://dx.doi.org/10.1162/jocn.2010.21555 Journal of Cognitive Neuroscience Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf MIT Press MIT Press |
| spellingShingle | Cromer, Jason Machon, Michelle Miller, Earl K. Rapid Association Learning in the Primate Prefrontal Cortex in the Behavioral Reversals |
| title | Rapid Association Learning in the Primate Prefrontal Cortex in the Behavioral Reversals |
| title_full | Rapid Association Learning in the Primate Prefrontal Cortex in the Behavioral Reversals |
| title_fullStr | Rapid Association Learning in the Primate Prefrontal Cortex in the Behavioral Reversals |
| title_full_unstemmed | Rapid Association Learning in the Primate Prefrontal Cortex in the Behavioral Reversals |
| title_short | Rapid Association Learning in the Primate Prefrontal Cortex in the Behavioral Reversals |
| title_sort | rapid association learning in the primate prefrontal cortex in the behavioral reversals |
| url | http://hdl.handle.net/1721.1/60320 |
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