No Association between Oxytocin Receptor (OXTR) Gene Polymorphisms and Experimentally Elicited Social Preferences
Background Oxytocin (OXT) has been implicated in a suite of complex social behaviors including observed choices in economic laboratory experiments. However, actual studies of associations between oxytocin receptor (OXTR) gene variants and experimentally elicited social preferences are rare. Metho...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Public Library of Science
2010
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| Online Access: | http://hdl.handle.net/1721.1/60358 |
| _version_ | 1811074362792476672 |
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| author | Cesarini, David Alexander Apicella, Coren L. Johannesson, Magnus Dawes, Christopher T. Lichtenstein, Paul Wallace, Björn Beauchamp, Jonathan Westberg, Lars |
| author2 | Massachusetts Institute of Technology. Department of Economics |
| author_facet | Massachusetts Institute of Technology. Department of Economics Cesarini, David Alexander Apicella, Coren L. Johannesson, Magnus Dawes, Christopher T. Lichtenstein, Paul Wallace, Björn Beauchamp, Jonathan Westberg, Lars |
| author_sort | Cesarini, David Alexander |
| collection | MIT |
| description | Background
Oxytocin (OXT) has been implicated in a suite of complex social behaviors including observed choices in economic laboratory experiments. However, actual studies of associations between oxytocin receptor (OXTR) gene variants and experimentally elicited social preferences are rare.
Methodology/Principal Findings
We test hypotheses of associations between social preferences, as measured by behavior in two economic games, and 9 single nucleotide polymorphisms (SNPs) of the OXTR gene in a sample of Swedish twins (n = 684). Two standard economic games, the dictator game and the trust game, both involving real monetary consequences, were used to elicit such preferences. After correction for multiple hypothesis testing, we found no significant associations between any of the 9 single nucleotide polymorphisms (SNPs) and behavior in either of the games.
Conclusion
We were unable to replicate the most significant association reported in previous research between the amount donated in a dictator game and an OXTR genetic variant. |
| first_indexed | 2024-09-23T09:47:53Z |
| format | Article |
| id | mit-1721.1/60358 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:47:53Z |
| publishDate | 2010 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | mit-1721.1/603582022-09-26T13:47:31Z No Association between Oxytocin Receptor (OXTR) Gene Polymorphisms and Experimentally Elicited Social Preferences Cesarini, David Alexander Apicella, Coren L. Johannesson, Magnus Dawes, Christopher T. Lichtenstein, Paul Wallace, Björn Beauchamp, Jonathan Westberg, Lars Massachusetts Institute of Technology. Department of Economics Cesarini, David Alexander Cesarini, David Alexander Background Oxytocin (OXT) has been implicated in a suite of complex social behaviors including observed choices in economic laboratory experiments. However, actual studies of associations between oxytocin receptor (OXTR) gene variants and experimentally elicited social preferences are rare. Methodology/Principal Findings We test hypotheses of associations between social preferences, as measured by behavior in two economic games, and 9 single nucleotide polymorphisms (SNPs) of the OXTR gene in a sample of Swedish twins (n = 684). Two standard economic games, the dictator game and the trust game, both involving real monetary consequences, were used to elicit such preferences. After correction for multiple hypothesis testing, we found no significant associations between any of the 9 single nucleotide polymorphisms (SNPs) and behavior in either of the games. Conclusion We were unable to replicate the most significant association reported in previous research between the amount donated in a dictator game and an OXTR genetic variant. 2010-12-22T16:21:31Z 2010-12-22T16:21:31Z 2010-06 2010-04 Article http://purl.org/eprint/type/JournalArticle 1932-6203 http://hdl.handle.net/1721.1/60358 Apicella, Coren L. et al. “No Association between Oxytocin Receptor (OXTR) Gene Polymorphisms and Experimentally Elicited Social Preferences.” PLoS ONE 5.6 (2010): e11153. en_US http://dx.doi.org/10.1371/journal.pone.0011153 PLoS ONE Creative Commons Attribution http://creativecommons.org/licenses/by/2.5/ application/pdf Public Library of Science PLoS |
| spellingShingle | Cesarini, David Alexander Apicella, Coren L. Johannesson, Magnus Dawes, Christopher T. Lichtenstein, Paul Wallace, Björn Beauchamp, Jonathan Westberg, Lars No Association between Oxytocin Receptor (OXTR) Gene Polymorphisms and Experimentally Elicited Social Preferences |
| title | No Association between Oxytocin Receptor (OXTR) Gene Polymorphisms and Experimentally Elicited Social Preferences |
| title_full | No Association between Oxytocin Receptor (OXTR) Gene Polymorphisms and Experimentally Elicited Social Preferences |
| title_fullStr | No Association between Oxytocin Receptor (OXTR) Gene Polymorphisms and Experimentally Elicited Social Preferences |
| title_full_unstemmed | No Association between Oxytocin Receptor (OXTR) Gene Polymorphisms and Experimentally Elicited Social Preferences |
| title_short | No Association between Oxytocin Receptor (OXTR) Gene Polymorphisms and Experimentally Elicited Social Preferences |
| title_sort | no association between oxytocin receptor oxtr gene polymorphisms and experimentally elicited social preferences |
| url | http://hdl.handle.net/1721.1/60358 |
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