Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics

Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics

Background Despite high potential for HIV-1 genetic variation, the emergence of some mutations is constrained by fitness costs, and may be associated with compensatory amino acid (AA) co-variation. To characterize the interplay between Cytotoxic T Lymphocyte (CTL)-mediated pressure and HIV-1 evol...

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Bibliographic Details
Main Authors: Brander, Christian, Walker, Bruce D., Goulder, Philip J. R., Rolland, Morgane, Carlson, Jonathan M., Manocheewa, Siriphan, Rousseau, Christine M., Raugi, Dana N., Learn, Gerald H., Maust, Brandon S., Coovadia, Hoosen M., Ndung'u, Thumbi, Heckerman, David, Mullins, James I., Swain, J. Victor, Lanxon-Cookson, Erinn, Deng, Wenjie
Other Authors: Ragon Institute of MGH, MIT and Harvard
Format: Article
Language:en_US
Published: Public Library of Science 2011
Online Access:http://hdl.handle.net/1721.1/60387

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