Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics

Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics

Background Despite high potential for HIV-1 genetic variation, the emergence of some mutations is constrained by fitness costs, and may be associated with compensatory amino acid (AA) co-variation. To characterize the interplay between Cytotoxic T Lymphocyte (CTL)-mediated pressure and HIV-1 evol...

ver descrição completa

Detalhes bibliográficos
Principais autores: Brander, Christian, Walker, Bruce D., Goulder, Philip J. R., Rolland, Morgane, Carlson, Jonathan M., Manocheewa, Siriphan, Rousseau, Christine M., Raugi, Dana N., Learn, Gerald H., Maust, Brandon S., Coovadia, Hoosen M., Ndung'u, Thumbi, Heckerman, David, Mullins, James I., Swain, J. Victor, Lanxon-Cookson, Erinn, Deng, Wenjie
Outros Autores: Ragon Institute of MGH, MIT and Harvard
Formato: Artigo
Idioma:en_US
Publicado em: Public Library of Science 2011
Acesso em linha:http://hdl.handle.net/1721.1/60387

Internet

http://hdl.handle.net/1721.1/60387

Registros relacionados