Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics

Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics

Background Despite high potential for HIV-1 genetic variation, the emergence of some mutations is constrained by fitness costs, and may be associated with compensatory amino acid (AA) co-variation. To characterize the interplay between Cytotoxic T Lymphocyte (CTL)-mediated pressure and HIV-1 evol...

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Bibliografiske detaljer
Main Authors: Brander, Christian, Walker, Bruce D., Goulder, Philip J. R., Rolland, Morgane, Carlson, Jonathan M., Manocheewa, Siriphan, Rousseau, Christine M., Raugi, Dana N., Learn, Gerald H., Maust, Brandon S., Coovadia, Hoosen M., Ndung'u, Thumbi, Heckerman, David, Mullins, James I., Swain, J. Victor, Lanxon-Cookson, Erinn, Deng, Wenjie
Andre forfattere: Ragon Institute of MGH, MIT and Harvard
Format: Article
Sprog:en_US
Udgivet: Public Library of Science 2011
Online adgang:http://hdl.handle.net/1721.1/60387

Internet

http://hdl.handle.net/1721.1/60387

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