Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics

Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics

Background Despite high potential for HIV-1 genetic variation, the emergence of some mutations is constrained by fitness costs, and may be associated with compensatory amino acid (AA) co-variation. To characterize the interplay between Cytotoxic T Lymphocyte (CTL)-mediated pressure and HIV-1 evol...

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מידע ביבליוגרפי
Main Authors: Brander, Christian, Walker, Bruce D., Goulder, Philip J. R., Rolland, Morgane, Carlson, Jonathan M., Manocheewa, Siriphan, Rousseau, Christine M., Raugi, Dana N., Learn, Gerald H., Maust, Brandon S., Coovadia, Hoosen M., Ndung'u, Thumbi, Heckerman, David, Mullins, James I., Swain, J. Victor, Lanxon-Cookson, Erinn, Deng, Wenjie
מחברים אחרים: Ragon Institute of MGH, MIT and Harvard
פורמט: Article
שפה:en_US
יצא לאור: Public Library of Science 2011
גישה מקוונת:http://hdl.handle.net/1721.1/60387

אינטרנט

http://hdl.handle.net/1721.1/60387

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