Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics

Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics

Background Despite high potential for HIV-1 genetic variation, the emergence of some mutations is constrained by fitness costs, and may be associated with compensatory amino acid (AA) co-variation. To characterize the interplay between Cytotoxic T Lymphocyte (CTL)-mediated pressure and HIV-1 evol...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Brander, Christian, Walker, Bruce D., Goulder, Philip J. R., Rolland, Morgane, Carlson, Jonathan M., Manocheewa, Siriphan, Rousseau, Christine M., Raugi, Dana N., Learn, Gerald H., Maust, Brandon S., Coovadia, Hoosen M., Ndung'u, Thumbi, Heckerman, David, Mullins, James I., Swain, J. Victor, Lanxon-Cookson, Erinn, Deng, Wenjie
Άλλοι συγγραφείς: Ragon Institute of MGH, MIT and Harvard
Μορφή: Άρθρο
Γλώσσα:en_US
Έκδοση: Public Library of Science 2011
Διαθέσιμο Online:http://hdl.handle.net/1721.1/60387

Διαδίκτυο

http://hdl.handle.net/1721.1/60387

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