Interfacing devices with cells
To detect electrical properties of cells, we have developed a method called iso-dielectric separation (IDS), where cells are placed in a spatially varying electric field and a spatially varying conductivity gradient that forces them to the location in a channel where their net polarizability (p) is...
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| Format: | Article |
| Language: | en_US |
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Institute of Electrical and Electronics Engineers
2011
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| Online Access: | http://hdl.handle.net/1721.1/60402 https://orcid.org/0000-0001-8898-2296 |
| _version_ | 1811072901279907840 |
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| author | Voldman, Joel |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Voldman, Joel |
| author_sort | Voldman, Joel |
| collection | MIT |
| description | To detect electrical properties of cells, we have developed a method called iso-dielectric separation (IDS), where cells are placed in a spatially varying electric field and a spatially varying conductivity gradient that forces them to the location in a channel where their net polarizability (p) is zero. At that location, the force on the cell, given by the dielectrophoretic force (F = p . delta E) will go to zero. Cells with different polarizabilities will end up in different locations in the channel, thus separating cells based upon electrical properties. The physical implementation of the method is described in Figure 3, and consists of a glass chip with patterned electrodes to create the field, along with microfluidics to deliver cells and create the conductivity gradient. |
| first_indexed | 2024-09-23T09:20:35Z |
| format | Article |
| id | mit-1721.1/60402 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:20:35Z |
| publishDate | 2011 |
| publisher | Institute of Electrical and Electronics Engineers |
| record_format | dspace |
| spelling | mit-1721.1/604022022-09-30T14:15:14Z Interfacing devices with cells Voldman, Joel Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Voldman, Joel Voldman, Joel To detect electrical properties of cells, we have developed a method called iso-dielectric separation (IDS), where cells are placed in a spatially varying electric field and a spatially varying conductivity gradient that forces them to the location in a channel where their net polarizability (p) is zero. At that location, the force on the cell, given by the dielectrophoretic force (F = p . delta E) will go to zero. Cells with different polarizabilities will end up in different locations in the channel, thus separating cells based upon electrical properties. The physical implementation of the method is described in Figure 3, and consists of a glass chip with patterned electrodes to create the field, along with microfluidics to deliver cells and create the conductivity gradient. 2011-01-07T16:27:26Z 2011-01-07T16:27:26Z 2009-12 2009-06 Article http://purl.org/eprint/type/ConferencePaper 978-1-4244-3528-9 INSPEC Accession Number: 11010439 http://hdl.handle.net/1721.1/60402 Voldman, J. “Interfacing devices with cells.” Device Research Conference, 2009. DRC 2009. 2009. 243-244. ©2009 IEEE. https://orcid.org/0000-0001-8898-2296 en_US http://dx.doi.org/10.1109/DRC.2009.5354848 Device Research Conference, 2009. DRC 2009 Attribution-Noncommercial-Share Alike 3.0 Unported http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Institute of Electrical and Electronics Engineers MIT web domain |
| spellingShingle | Voldman, Joel Interfacing devices with cells |
| title | Interfacing devices with cells |
| title_full | Interfacing devices with cells |
| title_fullStr | Interfacing devices with cells |
| title_full_unstemmed | Interfacing devices with cells |
| title_short | Interfacing devices with cells |
| title_sort | interfacing devices with cells |
| url | http://hdl.handle.net/1721.1/60402 https://orcid.org/0000-0001-8898-2296 |
| work_keys_str_mv | AT voldmanjoel interfacingdeviceswithcells |