New insights into oxidative folding
The oxidoreductase ERO1 (endoplasmic reticulum [ER] oxidoreductin 1) is thought to be crucial for disulfide bond formation in the ER. In this issue, Zito et al. (2010. J. Cell Biol. doi:10.1083/jcb.200911086) examine the division of labor between the two mammalian isoforms of ERO1 (ERO1-α and -β) in...
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| Format: | Article |
| Language: | en_US |
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Rockefeller University Press
2011
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| Online Access: | http://hdl.handle.net/1721.1/60570 |
| _version_ | 1811087274738188288 |
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| author | Sevier, Carolyn S. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Sevier, Carolyn S. |
| author_sort | Sevier, Carolyn S. |
| collection | MIT |
| description | The oxidoreductase ERO1 (endoplasmic reticulum [ER] oxidoreductin 1) is thought to be crucial for disulfide bond formation in the ER. In this issue, Zito et al. (2010. J. Cell Biol. doi:10.1083/jcb.200911086) examine the division of labor between the two mammalian isoforms of ERO1 (ERO1-α and -β) in oxidative folding. Their analysis reveals a selective role for ERO1-β in insulin production and a surprisingly minor contribution for either ERO1 isoform on immunoglobulin folding and secretion. |
| first_indexed | 2024-09-23T13:42:50Z |
| format | Article |
| id | mit-1721.1/60570 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:42:50Z |
| publishDate | 2011 |
| publisher | Rockefeller University Press |
| record_format | dspace |
| spelling | mit-1721.1/605702022-09-28T15:43:57Z New insights into oxidative folding Sevier, Carolyn S. Massachusetts Institute of Technology. Department of Biology Sevier, Carolyn S. Sevier, Carolyn S. The oxidoreductase ERO1 (endoplasmic reticulum [ER] oxidoreductin 1) is thought to be crucial for disulfide bond formation in the ER. In this issue, Zito et al. (2010. J. Cell Biol. doi:10.1083/jcb.200911086) examine the division of labor between the two mammalian isoforms of ERO1 (ERO1-α and -β) in oxidative folding. Their analysis reveals a selective role for ERO1-β in insulin production and a surprisingly minor contribution for either ERO1 isoform on immunoglobulin folding and secretion. 2011-01-14T16:45:27Z 2011-01-14T16:45:27Z 2010-03 2010-02 Article http://purl.org/eprint/type/JournalArticle 1540-8140 0021-9525 http://hdl.handle.net/1721.1/60570 Sevier, Carolyn S. “New insights into oxidative folding.” The Journal of Cell Biology 188.6 (2010): 757 -758. Copyright © 2010 by The Rockefeller University Press 20308423 en_US http://dx.doi.org/10.1083/jcb.201002114 Journal of Cell Biology Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Rockefeller University Press Rockefeller UP |
| spellingShingle | Sevier, Carolyn S. New insights into oxidative folding |
| title | New insights into oxidative folding |
| title_full | New insights into oxidative folding |
| title_fullStr | New insights into oxidative folding |
| title_full_unstemmed | New insights into oxidative folding |
| title_short | New insights into oxidative folding |
| title_sort | new insights into oxidative folding |
| url | http://hdl.handle.net/1721.1/60570 |
| work_keys_str_mv | AT seviercarolyns newinsightsintooxidativefolding |