αvβ3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration
Integrins are fundamental to the control of protrusion and motility in adherent cells. However, the mechanisms by which specific members of this receptor family cooperate in signaling to cytoskeletal and adhesion dynamics are poorly understood. Here, we show that the loss of β3 [beta 3] integrin in...
Main Authors: | Gertler, Frank, Worth, Daniel C., Hodivala-Dilke, Kairbaan, Robinson, Stephen D., King, Samantha J., Morton, Penny E., Humphries, Martin J., Parsons, Maddy |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | en_US |
Published: |
Rockefeller University Press
2011
|
Online Access: | http://hdl.handle.net/1721.1/60934 https://orcid.org/0000-0003-3214-4554 |
Similar Items
-
RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment
by: Alvaro Torres-Gomez, et al.
Published: (2020-05-01) -
RIAM, an Ena/VASP and Profilin Ligand, Interacts with Rap1-GTP and Mediates Rap1-Induced Adhesion
by: Lafuente, Esther M., et al.
Published: (2014) -
Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion
by: Julia Damiano-Guercio, et al.
Published: (2020-05-01) -
Expression of the phagocytic receptors αMβ2 and αXβ2 is controlled by RIAM, VASP and Vinculin in neutrophil-differentiated HL-60 cells
by: Alvaro Torres-Gomez, et al.
Published: (2022-09-01) -
Selectivity in subunit composition of Ena/VASP tetramers
by: Riquelme, Daisy Noelia, et al.
Published: (2016)