Estradiol-Induced Object Memory Consolidation in Middle-Aged Female Mice Requires Dorsal Hippocampal Extracellular Signal-Regulated Kinase and Phosphatidylinositol 3-Kinase Activation

Estradiol-Induced Object Memory Consolidation in Middle-Aged Female Mice Requires Dorsal Hippocampal Extracellular Signal-Regulated Kinase and Phosphatidylinositol 3-Kinase Activation

We previously demonstrated that dorsal hippocampal extracellular signal-regulated kinase (ERK) activation is necessary for 17β[beta]-estradiol (E2[E subscript 2]) to enhance novel object recognition in young ovariectomized mice (Fernandez et al., 2008). Here, we asked whether E2 [E subscript 2] has...

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Bibliographic Details
Main Authors: Lewis, Michael C., Fan, Lu, Zhao, Zaorui, Orr, Patrick T., Chambers, Cassie H., Frick, Karyn M.
Other Authors: McGovern Institute for Brain Research at MIT
Format: Article
Language:en_US
Published: Society for Neuroscience 2011
Online Access:http://hdl.handle.net/1721.1/60951

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