The design of a molecular assembly line based on biological molecules
Thesis (S.M.)--Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2003.
| Autor principal: | |
|---|---|
| Altres autors: | |
| Format: | Thesis |
| Idioma: | eng |
| Publicat: |
Massachusetts Institute of Technology
2011
|
| Matèries: | |
| Accés en línia: | http://hdl.handle.net/1721.1/61137 |
| _version_ | 1826199864011128832 |
|---|---|
| author | Chow, Brian, 1978- |
| author2 | Joseph M. Jacobson. |
| author_facet | Joseph M. Jacobson. Chow, Brian, 1978- |
| author_sort | Chow, Brian, 1978- |
| collection | MIT |
| description | Thesis (S.M.)--Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2003. |
| first_indexed | 2024-09-23T11:27:01Z |
| format | Thesis |
| id | mit-1721.1/61137 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T11:27:01Z |
| publishDate | 2011 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/611372019-04-12T12:43:46Z The design of a molecular assembly line based on biological molecules Chow, Brian, 1978- Joseph M. Jacobson. Massachusetts Institute of Technology. Dept. of Architecture. Program In Media Arts and Sciences. Massachusetts Institute of Technology. Dept. of Architecture. Program In Media Arts and Sciences. Architecture. Program In Media Arts and Sciences. Thesis (S.M.)--Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2003. Includes bibliographical references (leaves 78-83). A general scheme towards a "molecular assembly line" based on biological molecules is proposed, as well as its potential uses as a universal polymer scaffold in programmed assembly and molecular electronics. It is based on the principles of the biological molecules polyketide synthase and kinesin, and in some embodiments, may employ biomolecules like DNA as components of the system. The scheme entails the construction of a polymeric chain that moves a shuttle along the chain by controlling the interactions between the shuttle and individual monomer units using external inputs. The experimental work here particularly focuses on the design and synthesis of the monomer units and shuttles, as well as the mechanisms of control over the monomer/shuttle interactions that are required to construct the proposed polymer systems. Two approaches are explored, the first of which utilizes radio-frequency magnetic fields to selectively dehybridize DNA by coupling RF to covalently attached nanoparticle antennae. The second approach utilizes wavelength selective photocleavage of carbonyl bonds to control the equilibrium of a Michael reaction, and will demonstrate how one can construct a purely synthetic analogue of a polyketide synthase. by Brian Chow. S.M. 2011-02-23T14:18:43Z 2011-02-23T14:18:43Z 2003 2003 Thesis http://hdl.handle.net/1721.1/61137 53484093 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 83 leaves application/pdf Massachusetts Institute of Technology |
| spellingShingle | Architecture. Program In Media Arts and Sciences. Chow, Brian, 1978- The design of a molecular assembly line based on biological molecules |
| title | The design of a molecular assembly line based on biological molecules |
| title_full | The design of a molecular assembly line based on biological molecules |
| title_fullStr | The design of a molecular assembly line based on biological molecules |
| title_full_unstemmed | The design of a molecular assembly line based on biological molecules |
| title_short | The design of a molecular assembly line based on biological molecules |
| title_sort | design of a molecular assembly line based on biological molecules |
| topic | Architecture. Program In Media Arts and Sciences. |
| url | http://hdl.handle.net/1721.1/61137 |
| work_keys_str_mv | AT chowbrian1978 thedesignofamolecularassemblylinebasedonbiologicalmolecules AT chowbrian1978 designofamolecularassemblylinebasedonbiologicalmolecules |