Chondrogenic Differentiation of Adult Mesenchymal Stem Cells and Embryonic Stem Cells
Mesenchymal stem cell (MSC) contraction associated with chondrogenesis is attributed to the expression of alpha-smooth muscle actin (alpha-SMA). In this study, pluripotent embryonic carcinoma cells (ECCs) and MSCs were compared for cartilage histogensis. Both cell types expressed alpha-SMA in monola...
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| Format: | Article |
| Language: | en_US |
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Institute of Electrical and Electronics Engineers
2011
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| Online Access: | http://hdl.handle.net/1721.1/61655 |
| _version_ | 1826188423316111360 |
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| author | Shu, K. Thatte, H. Spector, Myron |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Shu, K. Thatte, H. Spector, Myron |
| author_sort | Shu, K. |
| collection | MIT |
| description | Mesenchymal stem cell (MSC) contraction associated with chondrogenesis is attributed to the expression of alpha-smooth muscle actin (alpha-SMA). In this study, pluripotent embryonic carcinoma cells (ECCs) and MSCs were compared for cartilage histogensis. Both cell types expressed alpha-SMA in monolayer. However, when cultured in pellets and in 3-D scaffolds, only MSCs contracted and formed glycosaminoglycan (GAG)- and type II collagen-rich tissue. Under these culture conditions, MSCs appear to be superior over ECCs for cartilage regeneration. |
| first_indexed | 2024-09-23T07:59:25Z |
| format | Article |
| id | mit-1721.1/61655 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T07:59:25Z |
| publishDate | 2011 |
| publisher | Institute of Electrical and Electronics Engineers |
| record_format | dspace |
| spelling | mit-1721.1/616552022-09-30T01:32:04Z Chondrogenic Differentiation of Adult Mesenchymal Stem Cells and Embryonic Stem Cells Shu, K. Thatte, H. Spector, Myron Harvard University--MIT Division of Health Sciences and Technology Spector, Myron Spector, Myron Shu, K. Thatte, H. Mesenchymal stem cell (MSC) contraction associated with chondrogenesis is attributed to the expression of alpha-smooth muscle actin (alpha-SMA). In this study, pluripotent embryonic carcinoma cells (ECCs) and MSCs were compared for cartilage histogensis. Both cell types expressed alpha-SMA in monolayer. However, when cultured in pellets and in 3-D scaffolds, only MSCs contracted and formed glycosaminoglycan (GAG)- and type II collagen-rich tissue. Under these culture conditions, MSCs appear to be superior over ECCs for cartilage regeneration. United States. Dept. of Veteran Affairs 2011-03-10T21:07:26Z 2011-03-10T21:07:26Z 2009-05 2009-04 Article http://purl.org/eprint/type/ConferencePaper 978-1-4244-4362-8 INSPEC Accession Number: 10666570 http://hdl.handle.net/1721.1/61655 Shu, K., H. Thatte, and M. Spector. “Chondrogenic differentiation of adult mesenchymal stem cells and embryonic stem cells.” Bioengineering Conference, 2009 IEEE 35th Annual Northeast. 2009. 1-2. © 2009 IEEE. en_US http://dx.doi.org/10.1109/NEBC.2009.4967739 IEEE 35th Annual Northeast Bioengineering Conference, 2009 Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Institute of Electrical and Electronics Engineers IEEE |
| spellingShingle | Shu, K. Thatte, H. Spector, Myron Chondrogenic Differentiation of Adult Mesenchymal Stem Cells and Embryonic Stem Cells |
| title | Chondrogenic Differentiation of Adult Mesenchymal Stem Cells and Embryonic Stem Cells |
| title_full | Chondrogenic Differentiation of Adult Mesenchymal Stem Cells and Embryonic Stem Cells |
| title_fullStr | Chondrogenic Differentiation of Adult Mesenchymal Stem Cells and Embryonic Stem Cells |
| title_full_unstemmed | Chondrogenic Differentiation of Adult Mesenchymal Stem Cells and Embryonic Stem Cells |
| title_short | Chondrogenic Differentiation of Adult Mesenchymal Stem Cells and Embryonic Stem Cells |
| title_sort | chondrogenic differentiation of adult mesenchymal stem cells and embryonic stem cells |
| url | http://hdl.handle.net/1721.1/61655 |
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