The Impact of Biomechanics in Tissue Engineering and Regenerative Medicine
Biomechanical factors profoundly influence the processes of tissue growth, development, maintenance, degeneration, and repair. Regenerative strategies to restore damaged or diseased tissues in vivo and create living tissue replacements in vitro have recently begun to harness advances in understandin...
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| Format: | Article |
| Language: | en_US |
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Mary Ann Liebert, Inc.
2011
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| Online Access: | http://hdl.handle.net/1721.1/61683 https://orcid.org/0000-0002-7232-304X |
| _version_ | 1826188114249383936 |
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| author | Butler, David L. Goldstein, Steven A. Guldberg, Robert E. Guo, X. Edward Kamm, Roger Dale Laurencin, Cato T. McIntire, Larry V. Mow, Van C. Nerem, Robert M. Sah, Robert L. Soslowsky, Louis J. Spilker, Robert L. Tranquillo, Robert T. |
| author2 | Massachusetts Institute of Technology. Department of Mechanical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Mechanical Engineering Butler, David L. Goldstein, Steven A. Guldberg, Robert E. Guo, X. Edward Kamm, Roger Dale Laurencin, Cato T. McIntire, Larry V. Mow, Van C. Nerem, Robert M. Sah, Robert L. Soslowsky, Louis J. Spilker, Robert L. Tranquillo, Robert T. |
| author_sort | Butler, David L. |
| collection | MIT |
| description | Biomechanical factors profoundly influence the processes of tissue growth, development, maintenance, degeneration, and repair. Regenerative strategies to restore damaged or diseased tissues in vivo and create living tissue replacements in vitro have recently begun to harness advances in understanding of how cells and tissues sense and adapt to their mechanical environment. It is clear that biomechanical considerations will be fundamental to the successful development of clinical therapies based on principles of tissue engineering and regenerative medicine for a broad range of musculoskeletal, cardiovascular, craniofacial, skin, urinary, and neural tissues. Biomechanical stimuli may in fact hold the key to producing regenerated tissues with high strength and endurance. However, many challenges remain, particularly for tissues that function within complex and demanding mechanical environments in vivo. This paper reviews the present role and potential impact of experimental and computational biomechanics in engineering functional tissues using several illustrative examples of past successes and future grand challenges. |
| first_indexed | 2024-09-23T07:54:48Z |
| format | Article |
| id | mit-1721.1/61683 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T07:54:48Z |
| publishDate | 2011 |
| publisher | Mary Ann Liebert, Inc. |
| record_format | dspace |
| spelling | mit-1721.1/616832022-09-23T09:33:59Z The Impact of Biomechanics in Tissue Engineering and Regenerative Medicine Butler, David L. Goldstein, Steven A. Guldberg, Robert E. Guo, X. Edward Kamm, Roger Dale Laurencin, Cato T. McIntire, Larry V. Mow, Van C. Nerem, Robert M. Sah, Robert L. Soslowsky, Louis J. Spilker, Robert L. Tranquillo, Robert T. Massachusetts Institute of Technology. Department of Mechanical Engineering Kamm, Roger Dale Kamm, Roger Dale Biomechanical factors profoundly influence the processes of tissue growth, development, maintenance, degeneration, and repair. Regenerative strategies to restore damaged or diseased tissues in vivo and create living tissue replacements in vitro have recently begun to harness advances in understanding of how cells and tissues sense and adapt to their mechanical environment. It is clear that biomechanical considerations will be fundamental to the successful development of clinical therapies based on principles of tissue engineering and regenerative medicine for a broad range of musculoskeletal, cardiovascular, craniofacial, skin, urinary, and neural tissues. Biomechanical stimuli may in fact hold the key to producing regenerated tissues with high strength and endurance. However, many challenges remain, particularly for tissues that function within complex and demanding mechanical environments in vivo. This paper reviews the present role and potential impact of experimental and computational biomechanics in engineering functional tissues using several illustrative examples of past successes and future grand challenges. 2011-03-11T20:57:39Z 2011-03-11T20:57:39Z 2009-12 2009-05 Article http://purl.org/eprint/type/JournalArticle 1937-3368 http://hdl.handle.net/1721.1/61683 Butler, David L. et al. “The Impact of Biomechanics in Tissue Engineering and Regenerative Medicine.” Tissue Engineering Part B: Reviews 15.4 (2009): 477-484. ©2009 Mary Ann Liebert, Inc. https://orcid.org/0000-0002-7232-304X en_US http://dx.doi.org/10.1089/ten.teb.2009.0340 Tissue Engineering. Part B Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Mary Ann Liebert, Inc. Mary Ann Liebert |
| spellingShingle | Butler, David L. Goldstein, Steven A. Guldberg, Robert E. Guo, X. Edward Kamm, Roger Dale Laurencin, Cato T. McIntire, Larry V. Mow, Van C. Nerem, Robert M. Sah, Robert L. Soslowsky, Louis J. Spilker, Robert L. Tranquillo, Robert T. The Impact of Biomechanics in Tissue Engineering and Regenerative Medicine |
| title | The Impact of Biomechanics in Tissue Engineering and Regenerative Medicine |
| title_full | The Impact of Biomechanics in Tissue Engineering and Regenerative Medicine |
| title_fullStr | The Impact of Biomechanics in Tissue Engineering and Regenerative Medicine |
| title_full_unstemmed | The Impact of Biomechanics in Tissue Engineering and Regenerative Medicine |
| title_short | The Impact of Biomechanics in Tissue Engineering and Regenerative Medicine |
| title_sort | impact of biomechanics in tissue engineering and regenerative medicine |
| url | http://hdl.handle.net/1721.1/61683 https://orcid.org/0000-0002-7232-304X |
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