The specificity and evolution of gene regulatory elements

The specificity and evolution of gene regulatory elements

Thesis (Ph. D.)--Massachusetts Institute of Technology, Computational and Systems Biology Program, 2010.

Bibliographic Details
Main Author:	Friedman, Robin Carl
Other Authors:	Christopher B. Burge and David P. Bartel.
Format:	Thesis
Language:	eng
Published:	Massachusetts Institute of Technology 2011
Subjects:	Computational and Systems Biology Program.
Online Access:	http://hdl.handle.net/1721.1/61790

Similar Items

Exploring the regulatory roles of microRNAs in mammalian development
by: Zheng, Grace Xinying
Published: (2010)

Integrative approaches for systematic reconstruction of regulatory circuits in mammals
by: Santos Botelho Oliveira Leite, Ana Paula
Published: (2013)

A constraint optimization framework for discovery of cellular signaling and regulatory networks
by: Huang, Shao-shan Carol
Published: (2011)

Uncovering the variability, regulatory roles and mutation rates of short tandem repeats
by: Willems, Thomas F. (Thomas Frederick)
Published: (2016)

Simultaneous computational discovery of DNA regulatory motifs and transcription factor binding constraints at high spatial resolution
by: Guo, Yuchun
Published: (2013)

Cell-type specific cholinergic modulation of the cortex
by: Chen, Naiyan
Published: (2014)

Rational drug combinations design against intratumoral heterogeneity and clonal evolution
by: Zhao, Boyang
Published: (2016)

Microbial adaptation, differentiation, and community structure
by: Friedman, Jonathan, Ph. D. Massachusetts Institute of Technology
Published: (2013)

Protein structure and interaction under environmental stress : from quality control recognition to evolution of collective behavior
by: Brock, Kelly Paige
Published: (2016)

Transcriptional and structural control of cell identity genes
by: Fan, Zi Peng
Published: (2015)

Bridging the gap between protein-tyrosine phosphorylation networks, metabolism and physiology in liver-specific PTP1b deletion mice
by: Miraldi, Emily R. (Emily Rae)
Published: (2012)

Computational methods for analyzing and modeling gene regulation and 3D genome organization
by: Belyaeva, Anastasiya.
Published: (2021)

Epigenetic and post-transcriptional regulation of gene expression in pluripotent stem cells, differentiation and metastasis
by: Cheng, Wu Albert
Published: (2014)

A C. elegans histone methyltransferase promotes spermatocyte gene expression, spermatid production and fertility
by: Engert, Christoph G
Published: (2017)

The gene regulatory network for breast cancer: Integrated regulatory landscape of cancer hallmarks
by: Frank eEmmert-Streib, et al.
Published: (2014-02-01)

Novel phylogenetic approaches to problems in microbial genomics
by: David, Lawrence A. (Lawrence Anthony)
Published: (2011)

Identifying a transcriptional signature for cell sensitivity to the cancer chemotherapy agent, BCNU
by: Valiathan, Chandni Rajan
Published: (2011)

Binding affinity of a small molecule to an amorphous polymer in a solvent
by: Chunsrivirot, Surasak
Published: (2011)

Genomic signatures of sex, selection and speciation in the microbial world
by: Shapiro, B. Jesse (Benjamin Jesse)
Published: (2011)

MicroRNAs : principles of target recognition and developmental roles
by: Agarwal, Vikram
Published: (2016)

Analysis of fecal biomarkers to impact clinical care and public health
by: Matus García, Mariana Guadalupe
Published: (2018)

Computational insights into the ecology of the human microbiota
by: Smillie, Christopher Scott
Published: (2016)

DNA methylation in early mammalian development
by: Chan, Michelle M. (Michelle Mei Wah)
Published: (2013)

Biochemically informed modeling of miRNA targeting efficacy
by: Lin, Kathy S.
Published: (2021)

A systems approach to uncovering the adaptive response of cancer to targeted therapies
by: Randall, Adrian Joseph
Published: (2012)

c-Myc regulates transcriptional pause release and is a global amplifier of transcription
by: Lin, Charles Yang
Published: (2013)

The role of unfolded states in collagen degradation
by: Salsas Escat, Ramon
Published: (2010)

Multivariate methods for the statistical analysis of hyperdimensional high-content screening data
by: Rameseder, Jonathan
Published: (2015)

Unfolding genome organization in interphase
by: Abdennur, Nezar(Nezar Alexander)
Published: (2019)

Understanding regulation of mRNA by RNA binding proteins
by: Robertson, Alexander De Jong
Published: (2014)

Deciphering the mitotic and meiotic phases of spermatogenesis in the mouse
by: Romer, Katherine A
Published: (2017)

Coordination of cellular force-generation during Drosophila ventral furrow formation
by: Xie, Shicong, Ph. D. Massachusetts Institute of Technology
Published: (2016)

Understanding the selective permeability of biological hydrogels
by: Witten, Jacob Julian Seid.
Published: (2019)

Measurement of rapid protein diffusion in the cytoplasm by photoconverted intensity profile expansion
by: Gura Sadovsky, Rotem
Published: (2016)

Predicting and testing determinants of histidine-kinase functions by leveraging protein sequence information
by: Ashenberg, Orr
Published: (2013)

Leveraging latent patterns in the study of living systems
by: Cleary, Brian(Brian Lowman)
Published: (2019)

Machine learning for understanding protein sequence and structure
by: Bepler, Tristan(Tristan Wendland)
Published: (2021)

Single-cell reporters for inflammatory caspase activity
by: Al-Obeidi, Arshed
Published: (2015)

Linking sequence to function in microbial genomics
by: Spencer, Sarah Jean
Published: (2018)

Pervasive degeneracy and epistasis in a protein-protein interface
by: Podgornaia, Anna Igorevna
Published: (2015)