3D cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2011
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| Online Access: | http://hdl.handle.net/1721.1/61871 |
| _version_ | 1811085038322712576 |
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| author | Jeon, Jessie Sungyun |
| author2 | Joseph Charest and Roger Kamm. |
| author_facet | Joseph Charest and Roger Kamm. Jeon, Jessie Sungyun |
| author_sort | Jeon, Jessie Sungyun |
| collection | MIT |
| description | Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010. |
| first_indexed | 2024-09-23T13:01:56Z |
| format | Thesis |
| id | mit-1721.1/61871 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T13:01:56Z |
| publishDate | 2011 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/618712019-04-11T03:36:58Z 3D cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform Three-dimensional cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform Jeon, Jessie Sungyun Joseph Charest and Roger Kamm. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Mechanical Engineering. Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010. Cataloged from PDF version of thesis. Includes bibliographical references (p. 48-51). A microfluidic system has been developed for studying the factors inducing different responses of cells in vascular system using a three-dimensional microenvironment. The devices have been transferred from PDMS to a platform in cyclic olefin copolymer (COC) which has advantages in terms of hydrophobicity, production by the more commercially-viable hot embossing technique, and amenability to surface treatments. Here the fabrication process is described and the new systems are characterized. Surface wettability, bond strength between the system body and a covering plastic film, and cell viability data are presented and compared to systems fabricated in PDMS. by Jessie Sungyun Jeon. S.M. 2011-03-24T20:19:28Z 2011-03-24T20:19:28Z 2010 2010 Thesis http://hdl.handle.net/1721.1/61871 705941957 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 51 p. application/pdf Massachusetts Institute of Technology |
| spellingShingle | Mechanical Engineering. Jeon, Jessie Sungyun 3D cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform |
| title | 3D cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform |
| title_full | 3D cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform |
| title_fullStr | 3D cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform |
| title_full_unstemmed | 3D cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform |
| title_short | 3D cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform |
| title_sort | 3d cyclic olefin copolymer coc microfluidic chip fabrication using hot embossing method for cell culture platform |
| topic | Mechanical Engineering. |
| url | http://hdl.handle.net/1721.1/61871 |
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