Self-sorting of deformable particles in a microfluidic circuit
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010.
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| Other Authors: | |
| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2011
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| Online Access: | http://hdl.handle.net/1721.1/62536 |
| _version_ | 1826217453358678016 |
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| author | Raafat, Mohamed Salem |
| author2 | Rohit N. Karnik. |
| author_facet | Rohit N. Karnik. Raafat, Mohamed Salem |
| author_sort | Raafat, Mohamed Salem |
| collection | MIT |
| description | Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010. |
| first_indexed | 2024-09-23T17:03:54Z |
| format | Thesis |
| id | mit-1721.1/62536 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T17:03:54Z |
| publishDate | 2011 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/625362019-04-12T09:51:54Z Self-sorting of deformable particles in a microfluidic circuit Raafat, Mohamed Salem Rohit N. Karnik. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Mechanical Engineering. Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010. Cataloged from PDF version of thesis. Includes bibliographical references (p. 54-57). In this thesis, a new microfluidic device is presented for sorting of deformable particles based on the hydrodynamic resistance induced in a microchannel. Hydrodynamic resistance can be related to physical properties, including size and deformability of the particle, and can also be influenced by particle-wall interactions, hence allowing sorting based on any of these characteristics. This device could find application in cell sorting and bioseparation for therapeutics, research, and point-of-care diagnostics, as well as in sorting of droplets and emulsions for research and industrial applications (e.g., pharmaceutics, food industry, etc.). The device design is carried out using an equivalent resistance model, and numerical simulations are used to validate the design. The device is fabricated in PDMS, flow velocities are characterized using particle streak velocimetry, and sorting experiments are conducted to sort deformable gelatin particles according to size, and droplets of water and glycerol according to deformability. A sorting resolution of approximately 1 pm was obtained when sorting based on size, and droplets of water and glycerol were sorted into separate streams when sorting based on deformability. The main strength of the device over existing technology lies in its simplicity: sorting is carried out passively in the microfluidic circuit, eliminating the need for additional detection or sorting modules. Moreover, the device could be easily customized to change the sorting parameter or the sorting threshold, and multiple devices can be combined in parallel (to increase throughput) or in series (to increase resolution). by Mohamed Salem Raafat. S.M. 2011-04-25T16:15:23Z 2011-04-25T16:15:23Z 2010 2010 Thesis http://hdl.handle.net/1721.1/62536 712950916 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 57 p. application/pdf Massachusetts Institute of Technology |
| spellingShingle | Mechanical Engineering. Raafat, Mohamed Salem Self-sorting of deformable particles in a microfluidic circuit |
| title | Self-sorting of deformable particles in a microfluidic circuit |
| title_full | Self-sorting of deformable particles in a microfluidic circuit |
| title_fullStr | Self-sorting of deformable particles in a microfluidic circuit |
| title_full_unstemmed | Self-sorting of deformable particles in a microfluidic circuit |
| title_short | Self-sorting of deformable particles in a microfluidic circuit |
| title_sort | self sorting of deformable particles in a microfluidic circuit |
| topic | Mechanical Engineering. |
| url | http://hdl.handle.net/1721.1/62536 |
| work_keys_str_mv | AT raafatmohamedsalem selfsortingofdeformableparticlesinamicrofluidiccircuit |