Long-term proton pump inhibitor administration, H pylori and gastric cancer: lessons from the gerbil
The association between chronic active gastritis and pre-neoplastic conditions as well as invasive cancer of the stomach was established several decades ago. The risk of progression depended on the severity and distribution of gastritis, with cancer, in particular, occurring in subjects with pan-gas...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
British Medical Association
2011
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| Online Access: | http://hdl.handle.net/1721.1/63604 https://orcid.org/0000-0001-9307-6116 |
| _version_ | 1811070961722589184 |
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| author | Fox, James G. Kuipers, Ernst J. |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Fox, James G. Kuipers, Ernst J. |
| author_sort | Fox, James G. |
| collection | MIT |
| description | The association between chronic active gastritis and pre-neoplastic conditions as well as invasive cancer of the stomach was established several decades ago. The risk of progression depended on the severity and distribution of gastritis, with cancer, in particular, occurring in subjects with pan-gastritis. Subsequently, Helicobacter pylori was recognised as the primary cause of chronic active gastritis, and it was demonstrated that the pattern of gastritis corresponded with the colonisation pattern of H pylori. We and others then showed both in animals and in humans that this pattern of colonisation and associated gastritis primarily depended on the level of acid output. 1 2 Although this hypothesis was widely accepted, it led to intense debate when dealing with the safety of long-term treatment with profound acid suppressors. An elegant, long-awaited study from Japan published in this issue of Gut ( see page 624) provides compelling evidence that the pattern of H pylori colonisation depends on acid output and that this influences the long-term progression to neoplasia. The current study was based on experiments
in gerbils, one of the well-established
animal models for the study gastric
disease induced by Helicobacter spp. |
| first_indexed | 2024-09-23T08:44:25Z |
| format | Article |
| id | mit-1721.1/63604 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:44:25Z |
| publishDate | 2011 |
| publisher | British Medical Association |
| record_format | dspace |
| spelling | mit-1721.1/636042022-09-30T10:52:05Z Long-term proton pump inhibitor administration, H pylori and gastric cancer: lessons from the gerbil Fox, James G. Kuipers, Ernst J. Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Division of Comparative Medicine Fox, James G. Fox, James G. The association between chronic active gastritis and pre-neoplastic conditions as well as invasive cancer of the stomach was established several decades ago. The risk of progression depended on the severity and distribution of gastritis, with cancer, in particular, occurring in subjects with pan-gastritis. Subsequently, Helicobacter pylori was recognised as the primary cause of chronic active gastritis, and it was demonstrated that the pattern of gastritis corresponded with the colonisation pattern of H pylori. We and others then showed both in animals and in humans that this pattern of colonisation and associated gastritis primarily depended on the level of acid output. 1 2 Although this hypothesis was widely accepted, it led to intense debate when dealing with the safety of long-term treatment with profound acid suppressors. An elegant, long-awaited study from Japan published in this issue of Gut ( see page 624) provides compelling evidence that the pattern of H pylori colonisation depends on acid output and that this influences the long-term progression to neoplasia. The current study was based on experiments in gerbils, one of the well-established animal models for the study gastric disease induced by Helicobacter spp. 2011-06-09T15:22:05Z 2011-06-09T15:22:05Z 2011-05 Article http://purl.org/eprint/type/JournalArticle 0017-5749 http://hdl.handle.net/1721.1/63604 Fox, James G., and Ernst J. Kuipers. “Long-term Proton Pump Inhibitor Administration, H Pylori and Gastric Cancer: Lessons from the Gerbil.” Gut 60.5 (2011) : 567 -568.© 2011 BMJ Publishing Group Ltd. https://orcid.org/0000-0001-9307-6116 en_US http://dx.doi.org/10.1136/gut.2010.229286 Gut Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf British Medical Association BMJ |
| spellingShingle | Fox, James G. Kuipers, Ernst J. Long-term proton pump inhibitor administration, H pylori and gastric cancer: lessons from the gerbil |
| title | Long-term proton pump inhibitor administration, H pylori and gastric cancer: lessons from the gerbil |
| title_full | Long-term proton pump inhibitor administration, H pylori and gastric cancer: lessons from the gerbil |
| title_fullStr | Long-term proton pump inhibitor administration, H pylori and gastric cancer: lessons from the gerbil |
| title_full_unstemmed | Long-term proton pump inhibitor administration, H pylori and gastric cancer: lessons from the gerbil |
| title_short | Long-term proton pump inhibitor administration, H pylori and gastric cancer: lessons from the gerbil |
| title_sort | long term proton pump inhibitor administration h pylori and gastric cancer lessons from the gerbil |
| url | http://hdl.handle.net/1721.1/63604 https://orcid.org/0000-0001-9307-6116 |
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