Neural Coding of Interaural Time Differences with Bilateral Cochlear Implants: Effects of Congenital Deafness
Human bilateral cochlear implant users do poorly on tasks involving interaural time differences (ITD), a cue that provides important benefits to the normal hearing, especially in challenging acoustic environments, yet the precision of neural ITD coding in acutely deafened, bilaterally implanted cats...
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| Format: | Article |
| Language: | en_US |
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Society for Neuroscience
2011
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| Online Access: | http://hdl.handle.net/1721.1/64453 https://orcid.org/0000-0003-1349-9608 |
| _version_ | 1811073580376522752 |
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| author | Noel, Victor Ryugo, David K. Delgutte, Bertrand Hancock, Kenneth E. |
| author2 | Massachusetts Institute of Technology. Research Laboratory of Electronics |
| author_facet | Massachusetts Institute of Technology. Research Laboratory of Electronics Noel, Victor Ryugo, David K. Delgutte, Bertrand Hancock, Kenneth E. |
| author_sort | Noel, Victor |
| collection | MIT |
| description | Human bilateral cochlear implant users do poorly on tasks involving interaural time differences (ITD), a cue that provides important benefits to the normal hearing, especially in challenging acoustic environments, yet the precision of neural ITD coding in acutely deafened, bilaterally implanted cats is essentially normal (Smith and Delgutte, 2007a). One explanation for this discrepancy is that the extended periods of binaural deprivation typically experienced by cochlear implant users degrades neural ITD sensitivity, by either impeding normal maturation of the neural circuitry or altering it later in life. To test this hypothesis, we recorded from single units in inferior colliculus of two groups of bilaterally implanted, anesthetized cats that contrast maximally in binaural experience: acutely deafened cats, which had normal binaural hearing until experimentation, and congenitally deaf white cats, which received no auditory inputs until the experiment. Rate responses of only half as many neurons showed significant ITD sensitivity to low-rate pulse trains in congenitally deaf cats compared with acutely deafened cats. For neurons that were ITD sensitive, ITD tuning was broader and best ITDs were more variable in congenitally deaf cats, leading to poorer ITD coding within the naturally occurring range. A signal detection model constrained by the observed physiology supports the idea that the degraded neural ITD coding resulting from deprivation of binaural experience contributes to poor ITD discrimination by human implantees. |
| first_indexed | 2024-09-23T09:34:54Z |
| format | Article |
| id | mit-1721.1/64453 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:34:54Z |
| publishDate | 2011 |
| publisher | Society for Neuroscience |
| record_format | dspace |
| spelling | mit-1721.1/644532022-09-30T15:27:29Z Neural Coding of Interaural Time Differences with Bilateral Cochlear Implants: Effects of Congenital Deafness Noel, Victor Ryugo, David K. Delgutte, Bertrand Hancock, Kenneth E. Massachusetts Institute of Technology. Research Laboratory of Electronics Delgutte, Bertrand Delgutte, Bertrand Human bilateral cochlear implant users do poorly on tasks involving interaural time differences (ITD), a cue that provides important benefits to the normal hearing, especially in challenging acoustic environments, yet the precision of neural ITD coding in acutely deafened, bilaterally implanted cats is essentially normal (Smith and Delgutte, 2007a). One explanation for this discrepancy is that the extended periods of binaural deprivation typically experienced by cochlear implant users degrades neural ITD sensitivity, by either impeding normal maturation of the neural circuitry or altering it later in life. To test this hypothesis, we recorded from single units in inferior colliculus of two groups of bilaterally implanted, anesthetized cats that contrast maximally in binaural experience: acutely deafened cats, which had normal binaural hearing until experimentation, and congenitally deaf white cats, which received no auditory inputs until the experiment. Rate responses of only half as many neurons showed significant ITD sensitivity to low-rate pulse trains in congenitally deaf cats compared with acutely deafened cats. For neurons that were ITD sensitive, ITD tuning was broader and best ITDs were more variable in congenitally deaf cats, leading to poorer ITD coding within the naturally occurring range. A signal detection model constrained by the observed physiology supports the idea that the degraded neural ITD coding resulting from deprivation of binaural experience contributes to poor ITD discrimination by human implantees. National Institutes of Health (U.S.) (Grant RO1 DC00575) National Institutes of Health (U.S.) (grant RO1 DC00232) National Institutes of Health (U.S.) (grant P30 DC005209) Advanced Bionics Corporation 2011-06-16T16:03:02Z 2011-06-16T16:03:02Z 2010-10 2010-08 Article http://purl.org/eprint/type/JournalArticle 0270-6474 http://hdl.handle.net/1721.1/64453 Hancock, Kenneth E., et al. "Neural Coding of Interaural Time Differences with Bilateral Cochlear Implants: Effects of Congenital Deafness." The Journal of Neuroscience, 20 October 2010, 30(42): 14068-14079. https://orcid.org/0000-0003-1349-9608 en_US http://dx.doi.org/10.1523/jneurosci.3213-10.2010 Journal of Neuroscience Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Society for Neuroscience SFN |
| spellingShingle | Noel, Victor Ryugo, David K. Delgutte, Bertrand Hancock, Kenneth E. Neural Coding of Interaural Time Differences with Bilateral Cochlear Implants: Effects of Congenital Deafness |
| title | Neural Coding of Interaural Time Differences with Bilateral Cochlear Implants: Effects of Congenital Deafness |
| title_full | Neural Coding of Interaural Time Differences with Bilateral Cochlear Implants: Effects of Congenital Deafness |
| title_fullStr | Neural Coding of Interaural Time Differences with Bilateral Cochlear Implants: Effects of Congenital Deafness |
| title_full_unstemmed | Neural Coding of Interaural Time Differences with Bilateral Cochlear Implants: Effects of Congenital Deafness |
| title_short | Neural Coding of Interaural Time Differences with Bilateral Cochlear Implants: Effects of Congenital Deafness |
| title_sort | neural coding of interaural time differences with bilateral cochlear implants effects of congenital deafness |
| url | http://hdl.handle.net/1721.1/64453 https://orcid.org/0000-0003-1349-9608 |
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