Stable Encoding of Task Structure Coexists with Flexible Coding of Task Sensorimotor Striatum
The sensorimotor striatum, as part of the brain's habit circuitry, has been suggested to store fixed action values as a result of stimulus-response learning and has been contrasted with a more flexible system that conditionally assigns values to behaviors. The stability of neural activity in th...
| Main Authors: | , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
American Physiological Society
2011
|
| Online Access: | http://hdl.handle.net/1721.1/64674 https://orcid.org/0000-0002-4326-7720 |
| _version_ | 1811074958985527296 |
|---|---|
| author | Kubota, Yasuo Liu, Jun Hu, Dan DeCoteau, William E. Eden, Uri T. Smith, Anne C. Graybiel, Ann M. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Kubota, Yasuo Liu, Jun Hu, Dan DeCoteau, William E. Eden, Uri T. Smith, Anne C. Graybiel, Ann M. |
| author_sort | Kubota, Yasuo |
| collection | MIT |
| description | The sensorimotor striatum, as part of the brain's habit circuitry, has been suggested to store fixed action values as a result of stimulus-response learning and has been contrasted with a more flexible system that conditionally assigns values to behaviors. The stability of neural activity in the sensorimotor striatum is thought to underlie not only normal habits but also addiction and clinical syndromes characterized by behavioral fixity. By recording in the sensorimotor striatum of mice, we asked whether neuronal activity acquired during procedural learning would be stable even if the sensory stimuli triggering the habitual behavior were altered. Contrary to expectation, both fixed and flexible activity patterns appeared. One, representing the global structure of the acquired behavior, was stable across changes in task cuing. The second, a fine-grain representation of task events, adjusted rapidly. Such dual forms of representation may be critical to allow motor and cognitive flexibility despite habitual performance. |
| first_indexed | 2024-09-23T09:58:09Z |
| format | Article |
| id | mit-1721.1/64674 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:58:09Z |
| publishDate | 2011 |
| publisher | American Physiological Society |
| record_format | dspace |
| spelling | mit-1721.1/646742022-09-30T18:00:27Z Stable Encoding of Task Structure Coexists with Flexible Coding of Task Sensorimotor Striatum Kubota, Yasuo Liu, Jun Hu, Dan DeCoteau, William E. Eden, Uri T. Smith, Anne C. Graybiel, Ann M. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Graybiel, Ann Kubota, Yasuo Liu, Jun Hu, Dan Graybiel, Ann M. The sensorimotor striatum, as part of the brain's habit circuitry, has been suggested to store fixed action values as a result of stimulus-response learning and has been contrasted with a more flexible system that conditionally assigns values to behaviors. The stability of neural activity in the sensorimotor striatum is thought to underlie not only normal habits but also addiction and clinical syndromes characterized by behavioral fixity. By recording in the sensorimotor striatum of mice, we asked whether neuronal activity acquired during procedural learning would be stable even if the sensory stimuli triggering the habitual behavior were altered. Contrary to expectation, both fixed and flexible activity patterns appeared. One, representing the global structure of the acquired behavior, was stable across changes in task cuing. The second, a fine-grain representation of task events, adjusted rapidly. Such dual forms of representation may be critical to allow motor and cognitive flexibility despite habitual performance. National Institute of Neurological Disorders and Stroke (U.S.) (Grant P50-NS038372) United States. Office of Naval Research (Grant N00014-04-1-0208) 2011-06-24T22:27:52Z 2011-06-24T22:27:52Z 2009-10 2009-06 Article http://purl.org/eprint/type/JournalArticle 0022-3077 1522-1598 http://hdl.handle.net/1721.1/64674 Kubota, Y. et al. “Stable Encoding of Task Structure Coexists With Flexible Coding of Task Events in Sensorimotor Striatum.” Journal of Neurophysiology 102.4 (2009) : 2142-2160. Copyright © 2009 The American Physiological Society https://orcid.org/0000-0002-4326-7720 en_US http://dx.doi.org/10.1152/jn.00522.2009 Journal of Neurophysiology Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf American Physiological Society Prof. Graybiel via Lisa Horowitz |
| spellingShingle | Kubota, Yasuo Liu, Jun Hu, Dan DeCoteau, William E. Eden, Uri T. Smith, Anne C. Graybiel, Ann M. Stable Encoding of Task Structure Coexists with Flexible Coding of Task Sensorimotor Striatum |
| title | Stable Encoding of Task Structure Coexists with Flexible Coding of Task Sensorimotor Striatum |
| title_full | Stable Encoding of Task Structure Coexists with Flexible Coding of Task Sensorimotor Striatum |
| title_fullStr | Stable Encoding of Task Structure Coexists with Flexible Coding of Task Sensorimotor Striatum |
| title_full_unstemmed | Stable Encoding of Task Structure Coexists with Flexible Coding of Task Sensorimotor Striatum |
| title_short | Stable Encoding of Task Structure Coexists with Flexible Coding of Task Sensorimotor Striatum |
| title_sort | stable encoding of task structure coexists with flexible coding of task sensorimotor striatum |
| url | http://hdl.handle.net/1721.1/64674 https://orcid.org/0000-0002-4326-7720 |
| work_keys_str_mv | AT kubotayasuo stableencodingoftaskstructurecoexistswithflexiblecodingoftasksensorimotorstriatum AT liujun stableencodingoftaskstructurecoexistswithflexiblecodingoftasksensorimotorstriatum AT hudan stableencodingoftaskstructurecoexistswithflexiblecodingoftasksensorimotorstriatum AT decoteauwilliame stableencodingoftaskstructurecoexistswithflexiblecodingoftasksensorimotorstriatum AT edenurit stableencodingoftaskstructurecoexistswithflexiblecodingoftasksensorimotorstriatum AT smithannec stableencodingoftaskstructurecoexistswithflexiblecodingoftasksensorimotorstriatum AT graybielannm stableencodingoftaskstructurecoexistswithflexiblecodingoftasksensorimotorstriatum |