Imaging mobile zinc in biology
Trafficking and regulation of mobile zinc pools influence cellular functions and pathological conditions in multiple organs, including brain, pancreas, and prostate. The quest for a dynamic description of zinc distribution and mobilization in live cells fuels the development of increasingly sophisti...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Elsevier Ltd.
2011
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| Online Access: | http://hdl.handle.net/1721.1/64757 https://orcid.org/0000-0002-2693-4982 |
| _version_ | 1826194266319224832 |
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| author | Tomat, Elisa Lippard, Stephen J. |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Tomat, Elisa Lippard, Stephen J. |
| author_sort | Tomat, Elisa |
| collection | MIT |
| description | Trafficking and regulation of mobile zinc pools influence cellular functions and pathological conditions in multiple organs, including brain, pancreas, and prostate. The quest for a dynamic description of zinc distribution and mobilization in live cells fuels the development of increasingly sophisticated probes. Detection systems that respond to zinc binding with changes of their fluorescence emission properties have provided sensitive tools for mobile zinc imaging, and fluorescence microscopy experiments have afforded depictions of zinc distribution within live cells and tissues. Both small-molecule and protein-based fluorescent probes can address complex imaging challenges, such as analyte quantification, site-specific sensor localization, and real-time detection. |
| first_indexed | 2024-09-23T09:53:25Z |
| format | Article |
| id | mit-1721.1/64757 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:53:25Z |
| publishDate | 2011 |
| publisher | Elsevier Ltd. |
| record_format | dspace |
| spelling | mit-1721.1/647572022-09-30T17:28:48Z Imaging mobile zinc in biology Tomat, Elisa Lippard, Stephen J. Massachusetts Institute of Technology. Department of Chemistry Lippard, Stephen J. Lippard, Stephen J. Tomat, Elisa Trafficking and regulation of mobile zinc pools influence cellular functions and pathological conditions in multiple organs, including brain, pancreas, and prostate. The quest for a dynamic description of zinc distribution and mobilization in live cells fuels the development of increasingly sophisticated probes. Detection systems that respond to zinc binding with changes of their fluorescence emission properties have provided sensitive tools for mobile zinc imaging, and fluorescence microscopy experiments have afforded depictions of zinc distribution within live cells and tissues. Both small-molecule and protein-based fluorescent probes can address complex imaging challenges, such as analyte quantification, site-specific sensor localization, and real-time detection. National Institute of General Medical Sciences (U.S.) (grant GM065519) 2011-07-07T14:20:05Z 2011-07-07T14:20:05Z 2010-01 Article http://purl.org/eprint/type/JournalArticle 1367-5931 1879-0402 http://hdl.handle.net/1721.1/64757 Tomat, Elisa, and Stephen J Lippard. “Imaging Mobile Zinc in Biology.” Current Opinion in Chemical Biology 14.2 (2010) : 225-230. https://orcid.org/0000-0002-2693-4982 en_US http://dx.doi.org/10.1016/j.cbpa.2009.12.010 Current Opinion in Chemical Biology Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Elsevier Ltd. Prof. Lippard via Erja Kajosalo |
| spellingShingle | Tomat, Elisa Lippard, Stephen J. Imaging mobile zinc in biology |
| title | Imaging mobile zinc in biology |
| title_full | Imaging mobile zinc in biology |
| title_fullStr | Imaging mobile zinc in biology |
| title_full_unstemmed | Imaging mobile zinc in biology |
| title_short | Imaging mobile zinc in biology |
| title_sort | imaging mobile zinc in biology |
| url | http://hdl.handle.net/1721.1/64757 https://orcid.org/0000-0002-2693-4982 |
| work_keys_str_mv | AT tomatelisa imagingmobilezincinbiology AT lippardstephenj imagingmobilezincinbiology |