Carboxylate as the Protonation Site in (Peroxo)diiron(III) Model Complexes of Soluble Methane Monooxygenase and Related Diiron Proteins

Carboxylate as the Protonation Site in (Peroxo)diiron(III) Model Complexes of Soluble Methane Monooxygenase and Related Diiron Proteins

Dioxygen activation by carboxylate-bridged diiron enzymes is involved in essential biological processes ranging from DNA synthesis and hydrocarbon metabolism to cell proliferation.1-3 The carboxylate-bridged diiron superfamily of proteins includes ribonucleotide reductase (RNR),4 Δ9 desaturase,5...

Full description

Bibliographic Details
Main Authors:	Do, Loi Hung, Hayashi, Takahiro, Moenne-Loccoz, Pierre, Lippard, Stephen J.
Other Authors:	Massachusetts Institute of Technology. Department of Chemistry
Format:	Article
Language:	en_US
Published:	American Chemical Society 2011
Online Access:	http://hdl.handle.net/1721.1/64759 https://orcid.org/0000-0002-2693-4982

Similar Items

Diiron Oxidation State Control of Substrate Access to the Active Site of Soluble Methane Monooxygenase Mediated by the Regulatory Component
by: Wang, Weixue, et al.
Published: (2015)

Modeling the Syn Disposition of Nitrogen Donors in Non-Heme Diiron Enzymes. Synthesis, Characterization, and Hydrogen Peroxide Reactivity of Diiron(III) Complexes with the Syn N-Donor Ligand H[subscript 2]BPG[subscript 2]DEV
by: Friedle, Simone, et al.
Published: (2013)

Evolution of strategies to prepare synthetic mimics of carboxylate-bridged diiron protein active sites
by: Do, Loi Hung, et al.
Published: (2017)

2-Phenoxypyridyl Dinucleating Ligands for Assembly of Diiron(II) Complexes: Efficient Reactivity with O[subscript 2] to Form (μ-Oxo)diiron(III) Units
by: Do, Loi Hung, et al.
Published: (2013)

Evaluating the Identity and Diiron Core Transformations of a (μ-Oxo)diiron(III) Complex Supported by Electron-Rich Tris(pyridyl-2-methyl)amine Ligands
by: Do, Loi Hung, et al.
Published: (2013)

Toward Functional Carboxylate-Bridged Diiron Protein Mimics: Achieving Stability and Conformational Flexibility Using a Macrocylic Ligand
by: Do, Loi Hung, et al.
Published: (2012)

Triptycene-Based, Carboxylate-Bridged Biomimetic Diiron(II) Complexes
by: Li, Yang, et al.
Published: (2015)

Active Site Threonine Facilitates Proton Transfer during Dioxygen Activation at the Diiron Center of Toluene/o-Xylene Monooxygenase Hydroxylase
by: Song, Woon Ju, et al.
Published: (2011)

Catalytic and Stoichiometric <i>Baeyer–Villiger</i> Oxidation Mediated by Nonheme Peroxo-Diiron(III), Acylperoxo, and Iodosylbenzene Iron(III) Intermediates
by: Dóra Lakk-Bogáth, et al.
Published: (2022-04-01)

Versatile Reactivity of a Solvent-Coordinated Diiron(II) Compound: Synthesis and Dioxygen Reactivity of a Mixed-Valent Fe [superscript II] Fe [superscript III] Species
by: Majumdar, Amit, et al.
Published: (2015)

Oxidation Reactions Performed by Soluble Methane Monooxygenase Hydroxylase Intermediates H[subscript peroxo] and Q Proceed by Distinct Mechanisms
by: Tinberg, Christine E., et al.
Published: (2011)

The Aging-Associated Enzyme CLK-1 is a Member of the Carboxylate-Bridged Diiron Family of Proteins
by: Behan, Rachel K., et al.
Published: (2011)

Disproportionation of H<sub>2</sub>O<sub>2</sub> Mediated by Diiron-Peroxo Complexes as Catalase Mimics
by: Dóra Lakk-Bogáth, et al.
Published: (2021-07-01)

Design and Synthesis of a Novel Triptycene-Based Ligand for Modeling Carboxylate-Bridged Diiron Enzyme Active Sites
by: Li, Yang, et al.
Published: (2013)

Current Challenges for Modeling Enzyme Active Sites by Biomimetic Synthetic Diiron Complexes
by: Friedle, Simone, et al.
Published: (2011)

Structural studies of bacterial multicomponent monooxygenases : insights into substrate specificity, diiron center tuning and component interactions
by: Sazinsky, Matthew H. (Matthew Howard), 1976-
Published: (2005)

[superscript 19]F NMR Study of Ligand Dynamics in Carboxylate-Bridged Diiron(II) Complexes Supported by a Macrocyclic Ligand
by: Minier, Mikael Antoine, et al.
Published: (2017)

Dioxygen Activation in Soluble Methane Monooxygenase
by: Tinberg, Christine E., et al.
Published: (2012)

Studies in biomimetic diiron(III) chemistry and zeolite-encapsulated iron complexes
by: Ward, Kevin L. (Kevin Lawrence)
Published: (2007)

Biomimetic carboxylate-bridged diiron complexes : from solution behavior to modeling the secondary coordination sphere
by: Minier, Mikael A. (Mikael Antoine)
Published: (2016)

Synthesis, Structure, and Bonding for Bis(permethylpentalene)diiron
by: Myers, W, et al.
Published: (2015)

Modeling the active sites of non-heme diiron metalloproteins with sterically hindered carboxylates and syn N-Donor ligands
by: Friedle, Simone, 1976-
Published: (2010)

Synthesis, Characterization, and Oxygenation Studies of Carboxylate-Bridged Diiron(II) Complexes with Aromatic Substrates Tethered to Pyridine Ligands and the Formation of a Unique Trinuclear Complex
by: Friedle, Simone, et al.
Published: (2013)

Ligand-centered oxidation in a diiron s-indacene complex
by: Roussel, P, et al.
Published: (2000)

Adding Diversity to Diiron Aminocarbyne Complexes with Amine Ligands
by: Chiara Saviozzi, et al.
Published: (2023-02-01)

The synthesis and reactivity of thiolate bridged diiron hexacarbonyl complexes
by: Hoke, Jeffrey Barmont
Published: (2015)

Electron Transfer Control in Soluble Methane Monooxygenase
by: Wang, Weixue, et al.
Published: (2015)

Mechanism of assembly of the tyrosyl radical-diiron(III) cofactor of E. coli ribonucleotide reductase
by: Tong, Wing Hang
Published: (2005)

Tracking a defined route for O2 migration in a dioxygen-activating diiron enzyme
by: Song, Woon Ju, et al.
Published: (2012)

Advances in non-heme diiron modeling chemistry : developing functional protein mimics through ligand design and understanding dioxygen activation
by: Do, Loi Hung
Published: (2011)

Effect of Redox Potential on Diiron-Mediated Disproportionation of Hydrogen Peroxide
by: Patrik Török, et al.
Published: (2023-03-01)

Model complexes for active sites of diiron metalloproteins, dioxygen reactivity and water effects
by: Yoon, Sungho, 1971-
Published: (2005)

Function of the Diiron Cluster of Escherichia coli Class Ia Ribonucleotide Reductase in Proton-Coupled Electron Transfer
by: Wörsdörfer, Bigna, et al.
Published: (2015)

Modeling the active sites of diiron and dicopper metalloproteins with napthyridine-, phthalazine-, and diethynylbenzene-based ligands
by: Kuzelka, Jane, 1975-
Published: (2006)

Use of sterically hindered carboxylate ligands to model structural and functional features of dioxygen-activating centers in non-heme diiron enzymes
by: Lee, Dongwhan, 1970-
Published: (2005)

A Comprehensive Analysis of the Metal–Nitrile Bonding in an Organo-Diiron System
by: Giulio Bresciani, et al.
Published: (2021-11-01)

Anticancer Diiron Vinyliminium Complexes: A Structure–Activity Relationship Study
by: Simona Braccini, et al.
Published: (2021-07-01)

Aging-Associated Enzyme Human Clock-1: Substrate-Mediated Reduction of the Diiron Center for 5-Demethoxyubiquinone Hydroxylation
by: Lu, Tsai-Te, et al.
Published: (2015)

Diiron Aminocarbyne Complexes with NCE<sup>−</sup> Ligands (E = O, S, Se)
by: Giulio Bresciani, et al.
Published: (2023-04-01)

Structures and Bonding in Hexacarbonyl Diiron Polyenes: Cycloheptatriene and 1,3,5-Cyclooctatriene
by: Min Zhang, et al.
Published: (2022-05-01)