Cell-Trappable Fluorescent Probes for Nitric Oxide Visualization in Living Cells
Two new cell-trappable fluorescent probes for nitric oxide (NO) are reported based on either incorporation of hydrolyzable esters or conjugation to aminodextran polymers. Both probes are highly selective for NO over other reactive oxygen and nitrogen species (RONS). The efficacy of these probes for...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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American Chemical Society
2011
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| Online Access: | http://hdl.handle.net/1721.1/64765 https://orcid.org/0000-0002-2693-4982 |
| _version_ | 1811079937541537792 |
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| author | Pluth, Michael D. McQuade, Lindsey E. Lippard, Stephen J. |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Pluth, Michael D. McQuade, Lindsey E. Lippard, Stephen J. |
| author_sort | Pluth, Michael D. |
| collection | MIT |
| description | Two new cell-trappable fluorescent probes for nitric oxide (NO) are reported based on either incorporation of hydrolyzable esters or conjugation to aminodextran polymers. Both probes are highly selective for NO over other reactive oxygen and nitrogen species (RONS). The efficacy of these probes for the fluorescence imaging of nitric oxide produced endogenously in Raw 264.7 cells is demonstrated. |
| first_indexed | 2024-09-23T11:22:31Z |
| format | Article |
| id | mit-1721.1/64765 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:22:31Z |
| publishDate | 2011 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | mit-1721.1/647652022-10-01T03:11:29Z Cell-Trappable Fluorescent Probes for Nitric Oxide Visualization in Living Cells Pluth, Michael D. McQuade, Lindsey E. Lippard, Stephen J. Massachusetts Institute of Technology. Department of Chemistry Lippard, Stephen J. Pluth, Michael D. McQuade, Lindsey E. Lippard, Stephen J. Two new cell-trappable fluorescent probes for nitric oxide (NO) are reported based on either incorporation of hydrolyzable esters or conjugation to aminodextran polymers. Both probes are highly selective for NO over other reactive oxygen and nitrogen species (RONS). The efficacy of these probes for the fluorescence imaging of nitric oxide produced endogenously in Raw 264.7 cells is demonstrated. National Science Foundation (U.S.) (grant CHE-0907905) National Institutes of Health (U.S.) (Postdoctoral Fellowship (5 F32 GM085930)) 2011-07-07T18:50:10Z 2011-07-07T18:50:10Z 2010-03 Article http://purl.org/eprint/type/JournalArticle 1523-7060 1523-7052 http://hdl.handle.net/1721.1/64765 Pluth, Michael D., Lindsey E. McQuade, and Stephen J. Lippard. “Cell-Trappable Fluorescent Probes for Nitric Oxide Visualization in Living Cells.” Organic Letters 12.10 (2010) : 2318-2321. https://orcid.org/0000-0002-2693-4982 en_US http://dx.doi.org/10.1021/ol1006289 Organic Letters Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society Prof. Lippard via Erja Kajosalo |
| spellingShingle | Pluth, Michael D. McQuade, Lindsey E. Lippard, Stephen J. Cell-Trappable Fluorescent Probes for Nitric Oxide Visualization in Living Cells |
| title | Cell-Trappable Fluorescent Probes for Nitric Oxide Visualization in Living Cells |
| title_full | Cell-Trappable Fluorescent Probes for Nitric Oxide Visualization in Living Cells |
| title_fullStr | Cell-Trappable Fluorescent Probes for Nitric Oxide Visualization in Living Cells |
| title_full_unstemmed | Cell-Trappable Fluorescent Probes for Nitric Oxide Visualization in Living Cells |
| title_short | Cell-Trappable Fluorescent Probes for Nitric Oxide Visualization in Living Cells |
| title_sort | cell trappable fluorescent probes for nitric oxide visualization in living cells |
| url | http://hdl.handle.net/1721.1/64765 https://orcid.org/0000-0002-2693-4982 |
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