Highly Effective Gene Transfection In Vivo by Alkylated Polyethylenimine
We mechanistically explored the effect of increased hydrophobicity of the polycation on the efficacy and specificity of gene delivery in mice. N-Alkylated linear PEIs with varying alkyl chain lengths and extent of substitution were synthesized and characterized by biophysical methods. Their in vivo...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Hindawi Pub. Corp.
2011
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| Online Access: | http://hdl.handle.net/1721.1/64795 https://orcid.org/0000-0003-3830-714X |