Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma
Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal c...
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| Format: | Article |
| Language: | en_US |
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Hindawi Pub. Corp.
2011
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| Online Access: | http://hdl.handle.net/1721.1/64800 https://orcid.org/0000-0003-2839-8228 |
| _version_ | 1826200275779584000 |
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| author | Hayashi, Takuma Horiuchi, Akiko Sano, Kenji Hiraoka, Nobuyoshi Kanai, Yae Shiozawa, Tanri Tonegawa, Susumu Konishi, Ikuo |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Hayashi, Takuma Horiuchi, Akiko Sano, Kenji Hiraoka, Nobuyoshi Kanai, Yae Shiozawa, Tanri Tonegawa, Susumu Konishi, Ikuo |
| author_sort | Hayashi, Takuma |
| collection | MIT |
| description | Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Importantly, a diagnostic-biomarker which distinguishes malignant LMS from benign tumor leiomyoma (LMA) is yet to be established. Accordingly, it is necessary to analyze risk factors associated with uterine LMS, in order to establish a treatment method. LMP2-deficient mice spontaneously develop uterine LMS, with a disease prevalence of ~40% by 14 months of age. We found LMP2 expression to be absent in human LMS, but present in human LMA. Therefore, defective LMP2 expression may be one of the risk factors for LMS. LMP2 is a potential diagnostic-biomarker for uterine LMS, and may be targeted-molecule for a new therapeutic approach. |
| first_indexed | 2024-09-23T11:34:00Z |
| format | Article |
| id | mit-1721.1/64800 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:34:00Z |
| publishDate | 2011 |
| publisher | Hindawi Pub. Corp. |
| record_format | dspace |
| spelling | mit-1721.1/648002022-10-01T04:26:22Z Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma Hayashi, Takuma Horiuchi, Akiko Sano, Kenji Hiraoka, Nobuyoshi Kanai, Yae Shiozawa, Tanri Tonegawa, Susumu Konishi, Ikuo Massachusetts Institute of Technology. Department of Biology Picower Institute for Learning and Memory Tonegawa, Susumu Tonegawa, Susumu Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Importantly, a diagnostic-biomarker which distinguishes malignant LMS from benign tumor leiomyoma (LMA) is yet to be established. Accordingly, it is necessary to analyze risk factors associated with uterine LMS, in order to establish a treatment method. LMP2-deficient mice spontaneously develop uterine LMS, with a disease prevalence of ~40% by 14 months of age. We found LMP2 expression to be absent in human LMS, but present in human LMA. Therefore, defective LMP2 expression may be one of the risk factors for LMS. LMP2 is a potential diagnostic-biomarker for uterine LMS, and may be targeted-molecule for a new therapeutic approach. Japan. Ministry of Education, Culture, Sports, Science and Technology 2011-07-13T19:54:00Z 2011-07-13T19:54:00Z 2011-01 2010-12 Article http://purl.org/eprint/type/JournalArticle 1369-1643 1357-714X http://hdl.handle.net/1721.1/64800 Takuma Hayashi, Akiko Horiuchi, Kenji Sano, et al., “Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma,” Sarcoma, vol. 2011, Article ID 476498, 6 pages, 2011. https://orcid.org/0000-0003-2839-8228 en_US http://dx.doi.org/10.1155/2011/476498 Sarcoma Creative Commons Attribution http://creativecommons.org/licenses/by/2.0/ application/pdf Hindawi Pub. Corp. Hindawi |
| spellingShingle | Hayashi, Takuma Horiuchi, Akiko Sano, Kenji Hiraoka, Nobuyoshi Kanai, Yae Shiozawa, Tanri Tonegawa, Susumu Konishi, Ikuo Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma |
| title | Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma |
| title_full | Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma |
| title_fullStr | Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma |
| title_full_unstemmed | Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma |
| title_short | Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma |
| title_sort | molecular approach to uterine leiomyosarcoma lmp2 deficient mice as an animal model of spontaneous uterine leiomyosarcoma |
| url | http://hdl.handle.net/1721.1/64800 https://orcid.org/0000-0003-2839-8228 |
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