Mutational Escape in HIV-1 CTL Epitopes Leads to Increased Binding to Inhibitory Myelomonocytic MHC Class I Receptors
Escape mutations in HIV-1 cytotoxic T cell (CTL) epitopes can abrogate recognition by the TCR of HIV-1-specific CD8+ T cells, but may also change interactions with alternative MHC class I receptors. Here, we show that mutational escape in three HLA-A11-, B8- and B7- restricted immunodominant HIV-1 C...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | en_US |
| Published: |
Public Library of Science
2011
|
| Online Access: | http://hdl.handle.net/1721.1/64947 |