Active scaffolds for on-demand drug and cell delivery
Porous biomaterials have been widely used as scaffolds in tissue engineering and cell-based therapies. The release of biological agents from conventional porous scaffolds is typically governed by molecular diffusion, material degradation, and cell migration, which do not allow for dynamic external r...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | en_US |
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National Academy of Sciences (U.S.)
2011
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| Online Access: | http://hdl.handle.net/1721.1/64971 |
| _version_ | 1826211185880465408 |
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| author | Zhao, Xuanhe Kim, Jaeyun Cezar, Christine A. Huebsch, Nathaniel David Lee, Kangwon Bouhadir, Kamal Mooney, David J. |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Zhao, Xuanhe Kim, Jaeyun Cezar, Christine A. Huebsch, Nathaniel David Lee, Kangwon Bouhadir, Kamal Mooney, David J. |
| author_sort | Zhao, Xuanhe |
| collection | MIT |
| description | Porous biomaterials have been widely used as scaffolds in tissue engineering and cell-based therapies. The release of biological agents from conventional porous scaffolds is typically governed by molecular diffusion, material degradation, and cell migration, which do not allow for dynamic external regulation. We present a new active porous scaffold that can be remotely controlled by a magnetic field to deliver various biological agents on demand. The active porous scaffold, in the form of a macroporous ferrogel, gives a large deformation and volume change of over 70% under a moderate magnetic field. The deformation and volume variation allows a new mechanism to trigger and enhance the release of various drugs including mitoxantrone, plasmid DNA, and a chemokine from the scaffold. The porous scaffold can also act as a depot of various cells, whose release can be controlled by external magnetic fields. |
| first_indexed | 2024-09-23T15:01:56Z |
| format | Article |
| id | mit-1721.1/64971 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:01:56Z |
| publishDate | 2011 |
| publisher | National Academy of Sciences (U.S.) |
| record_format | dspace |
| spelling | mit-1721.1/649712022-10-02T00:05:13Z Active scaffolds for on-demand drug and cell delivery Zhao, Xuanhe Kim, Jaeyun Cezar, Christine A. Huebsch, Nathaniel David Lee, Kangwon Bouhadir, Kamal Mooney, David J. Harvard University--MIT Division of Health Sciences and Technology Huebsch, Nathaniel David Huebsch, Nathaniel David Porous biomaterials have been widely used as scaffolds in tissue engineering and cell-based therapies. The release of biological agents from conventional porous scaffolds is typically governed by molecular diffusion, material degradation, and cell migration, which do not allow for dynamic external regulation. We present a new active porous scaffold that can be remotely controlled by a magnetic field to deliver various biological agents on demand. The active porous scaffold, in the form of a macroporous ferrogel, gives a large deformation and volume change of over 70% under a moderate magnetic field. The deformation and volume variation allows a new mechanism to trigger and enhance the release of various drugs including mitoxantrone, plasmid DNA, and a chemokine from the scaffold. The porous scaffold can also act as a depot of various cells, whose release can be controlled by external magnetic fields. Harvard University. Materials Research Science and Engineering Center National Institutes of Health (U.S.) National Institute of Dental and Craniofacial Research (U.S.) (Research Grant R01 DE019917) Harvard University. BASF Advanced Research Initiative United States. Defense Advanced Research Projects Agency (W911NF-10-0113) Pratt School of Engineering (Duke University) 2011-07-28T15:52:23Z 2011-07-28T15:52:23Z 2011-01 2010-06 Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/64971 Zhao, X. et al. “Active Scaffolds for On-demand Drug and Cell Delivery.” Proceedings of the National Academy of Sciences 108.1 (2011) : 67-72.©2011 by the National Academy of Sciences. en_US http://dx.doi.org/10.1073/pnas.1007862108 Proceedings of the National Academy of Sciences of the United States of America Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences (U.S.) PNAS |
| spellingShingle | Zhao, Xuanhe Kim, Jaeyun Cezar, Christine A. Huebsch, Nathaniel David Lee, Kangwon Bouhadir, Kamal Mooney, David J. Active scaffolds for on-demand drug and cell delivery |
| title | Active scaffolds for on-demand drug and cell delivery |
| title_full | Active scaffolds for on-demand drug and cell delivery |
| title_fullStr | Active scaffolds for on-demand drug and cell delivery |
| title_full_unstemmed | Active scaffolds for on-demand drug and cell delivery |
| title_short | Active scaffolds for on-demand drug and cell delivery |
| title_sort | active scaffolds for on demand drug and cell delivery |
| url | http://hdl.handle.net/1721.1/64971 |
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