Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo
Targeted delivery and controlled release of inactive platinum (Pt) prodrugs may offer a new approach to improve the efficacy and tolerability of the Pt family of drugs, which are used to treat 50% of all cancers today. Using prostate cancer (PCa) as a model disease, we previously described the engin...
Main Authors: | Dhar, Shanta, Kolishetti, Nagesh, Lippard, Stephen J., Farokhzad, Omid C. |
---|---|
Other Authors: | MIT-Harvard Center for Cancer Nanotechnology Excellence |
Format: | Article |
Language: | en_US |
Published: |
National Academy of Sciences (U.S.)
2011
|
Online Access: | http://hdl.handle.net/1721.1/65115 https://orcid.org/0000-0002-2693-4982 https://orcid.org/0000-0002-2640-3006 |
Similar Items
-
α[subscript v]β[subscript 3] Integrin-Targeted PLGA-PEG Nanoparticles for Enhanced Anti-tumor Efficacy of a Pt(IV) Prodrug
by: Graf, Nora, et al.
Published: (2013) -
Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy
by: Kolishetti, Nagesh, et al.
Published: (2013) -
Mitaplatin, a Potent Fusion of Cisplatin and the Orphan Drug Dichloroacetate
by: Lippard, Stephen J., et al.
Published: (2011) -
Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug
by: Xu, Xiaoyang, et al.
Published: (2014) -
Oxidative halogenation of cisplatin and carboplatin: synthesis, spectroscopy, and crystal and molecular structures of Pt(IV) prodrugs
by: Alexander, Sarah M., et al.
Published: (2015)