Layer bonding of solvent-cast thin films for pharmaceutical solid dosage forms
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010.
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | eng |
| Published: |
Massachusetts Institute of Technology
2011
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/1721.1/65307 |
| _version_ | 1826207425939636224 |
|---|---|
| author | Kim, Won, S.M. Massachusetts Institute of Technology |
| author2 | Jung-Hoon Chun. |
| author_facet | Jung-Hoon Chun. Kim, Won, S.M. Massachusetts Institute of Technology |
| author_sort | Kim, Won, S.M. Massachusetts Institute of Technology |
| collection | MIT |
| description | Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010. |
| first_indexed | 2024-09-23T13:49:28Z |
| format | Thesis |
| id | mit-1721.1/65307 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T13:49:28Z |
| publishDate | 2011 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/653072019-04-12T15:25:39Z Layer bonding of solvent-cast thin films for pharmaceutical solid dosage forms Kim, Won, S.M. Massachusetts Institute of Technology Jung-Hoon Chun. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Mechanical Engineering. Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010. Cataloged from PDF version of thesis. Includes bibliographical references (p. 81-84). In the pharmaceutical industry, the conventional tablet manufacturing process, a batch-based process based on solid powder handling, presents challenges such as inhomogeneous blending between Active Pharmaceutical Ingredients (APIs) and excipients, low yield, and low production rate. These difficulties can be resolved by the realization of a continuous manufacturing process through co-processing of APIs and excipients in the liquid-phase solution. A solvent-cast thin film, produced from liquid solution, can then be manufactured into tablets by way of a folding process. In order to design detailed compaction processes and machines, required compression pressure for layer bonding and mechanical properties of materials should also be investigated. The bonding strength of solvent-cast thin film layers was quantitatively measured by lap shear test. Based on this measurement, bonding threshold pressure was proposed as an indicator showing degree of bonding. At the same time, the layer bonding mechanism of solvent-cast thin films was interpreted as an interdiffusion of amorphous polymer chain end segments. In this context, relative contact area, polymer mobility, which is measured by glass transition temperature, and dwell time were proposed as critical factors in determining bonding threshold pressure. The relationships between those critical factors and process parameters such as surface roughness, residual water and excipient concentration, and compression rate were investigated. The mechanical and viscoelastic properties of solvent-cast thin films were also characterized. Solvent-cast thin films showed ductile-brittle transition, i.e., change of indentation hardness and strength factors among tensile properties with respect to residual water concentration. Changes of creep modulus and tensile properties at various stress levels and strain rates were also observed. by Won Kim. S.M. 2011-08-18T19:16:26Z 2011-08-18T19:16:26Z 2010 2010 Thesis http://hdl.handle.net/1721.1/65307 745767792 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 84 p. application/pdf Massachusetts Institute of Technology |
| spellingShingle | Mechanical Engineering. Kim, Won, S.M. Massachusetts Institute of Technology Layer bonding of solvent-cast thin films for pharmaceutical solid dosage forms |
| title | Layer bonding of solvent-cast thin films for pharmaceutical solid dosage forms |
| title_full | Layer bonding of solvent-cast thin films for pharmaceutical solid dosage forms |
| title_fullStr | Layer bonding of solvent-cast thin films for pharmaceutical solid dosage forms |
| title_full_unstemmed | Layer bonding of solvent-cast thin films for pharmaceutical solid dosage forms |
| title_short | Layer bonding of solvent-cast thin films for pharmaceutical solid dosage forms |
| title_sort | layer bonding of solvent cast thin films for pharmaceutical solid dosage forms |
| topic | Mechanical Engineering. |
| url | http://hdl.handle.net/1721.1/65307 |
| work_keys_str_mv | AT kimwonsmmassachusettsinstituteoftechnology layerbondingofsolventcastthinfilmsforpharmaceuticalsoliddosageforms |