Focused Microwave Thermotherapy for Preoperative Treatment of Invasive Breast Cancer: A Review of Clinical Studies
Background: Preoperative focused microwave thermotherapy (FMT) is a promising method for targeted treatment of breast cancer cells. Results of four multi-institutional clinical studies of preoperative FMT for treating invasive carcinomas in the intact breast are reviewed. Methods: Externally...
| Main Authors: | , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Springer New York
2011
|
| Online Access: | http://hdl.handle.net/1721.1/65389 |
| _version_ | 1826210907262287872 |
|---|---|
| author | Dooley, William C. Vargas, Hernan I. Fenn, Alan J. Tomaselli, Mary Beth Harness, Jay K. |
| author2 | Lincoln Laboratory |
| author_facet | Lincoln Laboratory Dooley, William C. Vargas, Hernan I. Fenn, Alan J. Tomaselli, Mary Beth Harness, Jay K. |
| author_sort | Dooley, William C. |
| collection | MIT |
| description | Background:
Preoperative focused microwave thermotherapy (FMT) is a promising method for targeted treatment of breast cancer cells. Results of four multi-institutional clinical studies of preoperative FMT for treating invasive carcinomas in the intact breast are reviewed.
Methods:
Externally applied wide-field adaptive phased-array FMT has been investigated both as a preoperative heat-alone ablation treatment and as a combination treatment with preoperative anthracycline-based chemotherapy for breast tumors ranging in ultrasound-measured size from 0.8 to 7.8 cm.
Results:
In phase I, eight of ten (80%) patients receiving a single low dose of FMT prior to receiving mastectomy had a partial tumor response quantified by either ultrasound measurements of tumor volume reduction or by pathologic cell kill. In phase II, the FMT thermal dose was increased to establish a threshold dose to induce 100% pathologic tumor cell kill for invasive carcinomas prior to breast-conserving surgery (BCS). In a randomized study for patients with early-stage invasive breast cancer, of those patients receiving preoperative FMT at ablative temperatures, 0 of 34 (0%) patients had positive tumor margins, whereas positive margins occurred in 4 of 41 (9.8%) of patients receiving BCS alone (P = 0.13). In a randomized study for patients with large tumors, based on ultrasound measurements the median tumor volume reduction was 88.4% (n = 14) for patients receiving FMT and neoadjuvant chemotherapy, compared with 58.8% (n = 10) reduction in the neoadjuvant chemotherapy-alone arm (P = 0.048).
Conclusions:
Wide-field adaptive phased-array FMT can be safely administered in a preoperative setting, and data from randomized studies suggest both a reduction in positive tumor margins as a heat-alone treatment for early-stage breast cancer and a reduction in tumor volume when used in combination with anthracycline-based chemotherapy for patients with large breast cancer tumors. Larger randomized studies are required to verify these conclusions. |
| first_indexed | 2024-09-23T14:57:21Z |
| format | Article |
| id | mit-1721.1/65389 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:57:21Z |
| publishDate | 2011 |
| publisher | Springer New York |
| record_format | dspace |
| spelling | mit-1721.1/653892021-09-09T17:01:02Z Focused Microwave Thermotherapy for Preoperative Treatment of Invasive Breast Cancer: A Review of Clinical Studies Dooley, William C. Vargas, Hernan I. Fenn, Alan J. Tomaselli, Mary Beth Harness, Jay K. Lincoln Laboratory Fenn, Alan J. Fenn, Alan J. Background: Preoperative focused microwave thermotherapy (FMT) is a promising method for targeted treatment of breast cancer cells. Results of four multi-institutional clinical studies of preoperative FMT for treating invasive carcinomas in the intact breast are reviewed. Methods: Externally applied wide-field adaptive phased-array FMT has been investigated both as a preoperative heat-alone ablation treatment and as a combination treatment with preoperative anthracycline-based chemotherapy for breast tumors ranging in ultrasound-measured size from 0.8 to 7.8 cm. Results: In phase I, eight of ten (80%) patients receiving a single low dose of FMT prior to receiving mastectomy had a partial tumor response quantified by either ultrasound measurements of tumor volume reduction or by pathologic cell kill. In phase II, the FMT thermal dose was increased to establish a threshold dose to induce 100% pathologic tumor cell kill for invasive carcinomas prior to breast-conserving surgery (BCS). In a randomized study for patients with early-stage invasive breast cancer, of those patients receiving preoperative FMT at ablative temperatures, 0 of 34 (0%) patients had positive tumor margins, whereas positive margins occurred in 4 of 41 (9.8%) of patients receiving BCS alone (P = 0.13). In a randomized study for patients with large tumors, based on ultrasound measurements the median tumor volume reduction was 88.4% (n = 14) for patients receiving FMT and neoadjuvant chemotherapy, compared with 58.8% (n = 10) reduction in the neoadjuvant chemotherapy-alone arm (P = 0.048). Conclusions: Wide-field adaptive phased-array FMT can be safely administered in a preoperative setting, and data from randomized studies suggest both a reduction in positive tumor margins as a heat-alone treatment for early-stage breast cancer and a reduction in tumor volume when used in combination with anthracycline-based chemotherapy for patients with large breast cancer tumors. Larger randomized studies are required to verify these conclusions. 2011-08-26T13:59:54Z 2011-08-26T13:59:54Z 2009-12 2009-10 Article http://purl.org/eprint/type/JournalArticle 1068-9265 1534-4681 http://hdl.handle.net/1721.1/65389 Dooley, William C. et al. “Focused Microwave Thermotherapy for Preoperative Treatment of Invasive Breast Cancer: A Review of Clinical Studies.” Annals of Surgical Oncology 17.4 (2009) : 1076-1093. en_US http://dx.doi.org/10.1245/s10434-009-0872-z Annals of Surgical Oncology Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Springer New York Fenn |
| spellingShingle | Dooley, William C. Vargas, Hernan I. Fenn, Alan J. Tomaselli, Mary Beth Harness, Jay K. Focused Microwave Thermotherapy for Preoperative Treatment of Invasive Breast Cancer: A Review of Clinical Studies |
| title | Focused Microwave Thermotherapy for Preoperative Treatment of Invasive Breast Cancer: A Review of Clinical Studies |
| title_full | Focused Microwave Thermotherapy for Preoperative Treatment of Invasive Breast Cancer: A Review of Clinical Studies |
| title_fullStr | Focused Microwave Thermotherapy for Preoperative Treatment of Invasive Breast Cancer: A Review of Clinical Studies |
| title_full_unstemmed | Focused Microwave Thermotherapy for Preoperative Treatment of Invasive Breast Cancer: A Review of Clinical Studies |
| title_short | Focused Microwave Thermotherapy for Preoperative Treatment of Invasive Breast Cancer: A Review of Clinical Studies |
| title_sort | focused microwave thermotherapy for preoperative treatment of invasive breast cancer a review of clinical studies |
| url | http://hdl.handle.net/1721.1/65389 |
| work_keys_str_mv | AT dooleywilliamc focusedmicrowavethermotherapyforpreoperativetreatmentofinvasivebreastcancerareviewofclinicalstudies AT vargashernani focusedmicrowavethermotherapyforpreoperativetreatmentofinvasivebreastcancerareviewofclinicalstudies AT fennalanj focusedmicrowavethermotherapyforpreoperativetreatmentofinvasivebreastcancerareviewofclinicalstudies AT tomasellimarybeth focusedmicrowavethermotherapyforpreoperativetreatmentofinvasivebreastcancerareviewofclinicalstudies AT harnessjayk focusedmicrowavethermotherapyforpreoperativetreatmentofinvasivebreastcancerareviewofclinicalstudies |