Mutation of HIV-1 Genomes in a Clinical Population Treated with the Mutagenic Nucleoside KP1461

Mutation of HIV-1 Genomes in a Clinical Population Treated with the Mutagenic Nucleoside KP1461

The deoxycytidine analog KP1212, and its prodrug KP1461, are prototypes of a new class of antiretroviral drugs designed to increase viral mutation rates, with the goal of eventually causing the collapse of the viral population. Here we present an extensive analysis of viral sequences from HIV-1 infe...

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Bibliographic Details
Main Authors: Mullins, James I., Heath, Laura, Hughes, James P., Kicha, Jessica, Styrchak, Sheila, Wong, Kim G., Rao, Ushnal, Hansen, Alexis, Harris, Kevin S., Laurent, Jean-Pierre, Li, Deyu, Simpson, Jeffrey H., Essigmann, John M., Loeb, Lawrence A., Parkins, Jeffrey
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Public Library of Science 2011
Online Access:http://hdl.handle.net/1721.1/65401
https://orcid.org/0000-0002-2196-5691

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