Microworm optode sensors limit particle diffusion to enable in vivo measurements
There have been a variety of nanoparticles created for in vivo uses ranging from gene and drug delivery to tumor imaging and physiological monitoring. The use of nanoparticles to measure physiological conditions while being fluorescently addressed through the skin provides an ideal method toward min...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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National Academy of Sciences
2011
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| Online Access: | http://hdl.handle.net/1721.1/65412 https://orcid.org/0000-0001-6127-1056 |
| _version_ | 1811097142398287872 |
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| author | Ozaydin-Ince, Gozde Dubach, J. Matthew Gleason, Karen K. Clark, Heather A. |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Ozaydin-Ince, Gozde Dubach, J. Matthew Gleason, Karen K. Clark, Heather A. |
| author_sort | Ozaydin-Ince, Gozde |
| collection | MIT |
| description | There have been a variety of nanoparticles created for in vivo uses ranging from gene and drug delivery to tumor imaging and physiological monitoring. The use of nanoparticles to measure physiological conditions while being fluorescently addressed through the skin provides an ideal method toward minimally invasive health monitoring. Here we create unique particles that have all the necessary physical characteristics to serve as in vivo reporters, but with minimized diffusion from the point of injection. These particles, called microworms, have a cylindrical shape coated with a biocompatible porous membrane that possesses a large surface-area-to-volume ratio while maintaining a large hydrodynamic radius. We use these microworms to create fluorescent sodium sensors for use as in vivo sodium concentration detectors after subcutaneous injection. However, the microworm concept has the potential to extend to the immobilization of other types of polymers for continuous physiological detection or delivery of molecules. |
| first_indexed | 2024-09-23T16:55:00Z |
| format | Article |
| id | mit-1721.1/65412 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:55:00Z |
| publishDate | 2011 |
| publisher | National Academy of Sciences |
| record_format | dspace |
| spelling | mit-1721.1/654122022-10-03T09:08:01Z Microworm optode sensors limit particle diffusion to enable in vivo measurements Ozaydin-Ince, Gozde Dubach, J. Matthew Gleason, Karen K. Clark, Heather A. Massachusetts Institute of Technology. Department of Chemical Engineering Gleason, Karen K. Ozaydin-Ince, Gozde Gleason, Karen K. There have been a variety of nanoparticles created for in vivo uses ranging from gene and drug delivery to tumor imaging and physiological monitoring. The use of nanoparticles to measure physiological conditions while being fluorescently addressed through the skin provides an ideal method toward minimally invasive health monitoring. Here we create unique particles that have all the necessary physical characteristics to serve as in vivo reporters, but with minimized diffusion from the point of injection. These particles, called microworms, have a cylindrical shape coated with a biocompatible porous membrane that possesses a large surface-area-to-volume ratio while maintaining a large hydrodynamic radius. We use these microworms to create fluorescent sodium sensors for use as in vivo sodium concentration detectors after subcutaneous injection. However, the microworm concept has the potential to extend to the immobilization of other types of polymers for continuous physiological detection or delivery of molecules. United States. Army through the Institute for Soldier Nanotechnologies (contract DAAD-19-02-D-0002 with the US Army Research Office) National Institutes of Health (U.S.) (grant 01GM084366) Northeastern University. Integrative Graduate Education and Research Traineeship Nanomedicine Science and Technology program 2011-08-26T17:15:35Z 2011-08-26T17:15:35Z 2011-02 2010-10 Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/65412 Ozaydin-Ince, G. et al. “Microworm Optode Sensors Limit Particle Diffusion to Enable in Vivo Measurements.” Proceedings of the National Academy of Sciences 108.7 (2011) : 2656-2661. Copyright ©2011 by the National Academy of Sciences 21282619 https://orcid.org/0000-0001-6127-1056 en_US http://dx.doi.org/10.1073/pnas.1015544108 Proceedings of the National Academy of Sciences of the United States of America Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences PNAS |
| spellingShingle | Ozaydin-Ince, Gozde Dubach, J. Matthew Gleason, Karen K. Clark, Heather A. Microworm optode sensors limit particle diffusion to enable in vivo measurements |
| title | Microworm optode sensors limit particle diffusion to enable in vivo measurements |
| title_full | Microworm optode sensors limit particle diffusion to enable in vivo measurements |
| title_fullStr | Microworm optode sensors limit particle diffusion to enable in vivo measurements |
| title_full_unstemmed | Microworm optode sensors limit particle diffusion to enable in vivo measurements |
| title_short | Microworm optode sensors limit particle diffusion to enable in vivo measurements |
| title_sort | microworm optode sensors limit particle diffusion to enable in vivo measurements |
| url | http://hdl.handle.net/1721.1/65412 https://orcid.org/0000-0001-6127-1056 |
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