Probing structural and dynamical transitions in polymer globules by force
The dynamics of proteins and biopolymers play a crucial role in their function. By using Brownian dynamics we show that polymer globules, which serve as a model system for proteins, undergo a size-dependent dynamical transition from a liquid-like state at high T to a frozen state at low T with a rel...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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American Physical Society
2011
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| Online Access: | http://hdl.handle.net/1721.1/65552 https://orcid.org/0000-0001-5554-1283 |
| _version_ | 1811091448414601216 |
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| author | Sing, Charles E. Einert, Thomas R. Netz, Roland R. Alexander-Katz, Alfredo |
| author2 | Massachusetts Institute of Technology. Department of Materials Science and Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Materials Science and Engineering Sing, Charles E. Einert, Thomas R. Netz, Roland R. Alexander-Katz, Alfredo |
| author_sort | Sing, Charles E. |
| collection | MIT |
| description | The dynamics of proteins and biopolymers play a crucial role in their function. By using Brownian dynamics we show that polymer globules, which serve as a model system for proteins, undergo a size-dependent dynamical transition from a liquid-like state at high T to a frozen state at low T with a relaxation time that diverges at the transition point. Furthermore, a stretch-induced melting transition is shown to be readily controlled by external forces that exploit the polymer connectivity to modify the size of the globule. This pathway could be a general route to enhance the rate of conformational changes in naturally occurring biopolymers. |
| first_indexed | 2024-09-23T15:02:35Z |
| format | Article |
| id | mit-1721.1/65552 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:02:35Z |
| publishDate | 2011 |
| publisher | American Physical Society |
| record_format | dspace |
| spelling | mit-1721.1/655522022-10-02T00:12:05Z Probing structural and dynamical transitions in polymer globules by force Sing, Charles E. Einert, Thomas R. Netz, Roland R. Alexander-Katz, Alfredo Massachusetts Institute of Technology. Department of Materials Science and Engineering Alexander-Katz, Alfredo Sing, Charles E. Alexander-Katz, Alfredo The dynamics of proteins and biopolymers play a crucial role in their function. By using Brownian dynamics we show that polymer globules, which serve as a model system for proteins, undergo a size-dependent dynamical transition from a liquid-like state at high T to a frozen state at low T with a relaxation time that diverges at the transition point. Furthermore, a stretch-induced melting transition is shown to be readily controlled by external forces that exploit the polymer connectivity to modify the size of the globule. This pathway could be a general route to enhance the rate of conformational changes in naturally occurring biopolymers. National Defense Science and Engineering Graduate Fellowship National Science Foundation (U.S.). Career Program Elitenetzwerk Bayern in the framework of CompInt 2011-08-30T18:34:48Z 2011-08-30T18:34:48Z 2011-04 2011-01 Article http://purl.org/eprint/type/JournalArticle 1539-3755 1550-2376 http://hdl.handle.net/1721.1/65552 Sing, Charles et al. “Probing Structural and Dynamical Transitions in Polymer Globules by Force.” Physical Review E 83.4 (2011) ©2011 American Physical Society https://orcid.org/0000-0001-5554-1283 en_US http://dx.doi.org/10.1103/PhysRevE.83.040801 Physical Review E Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Physical Society APS |
| spellingShingle | Sing, Charles E. Einert, Thomas R. Netz, Roland R. Alexander-Katz, Alfredo Probing structural and dynamical transitions in polymer globules by force |
| title | Probing structural and dynamical transitions in polymer globules by force |
| title_full | Probing structural and dynamical transitions in polymer globules by force |
| title_fullStr | Probing structural and dynamical transitions in polymer globules by force |
| title_full_unstemmed | Probing structural and dynamical transitions in polymer globules by force |
| title_short | Probing structural and dynamical transitions in polymer globules by force |
| title_sort | probing structural and dynamical transitions in polymer globules by force |
| url | http://hdl.handle.net/1721.1/65552 https://orcid.org/0000-0001-5554-1283 |
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