A Yeast Model of FUS/TLS-Dependent Cytotoxicity

A Yeast Model of FUS/TLS-Dependent Cytotoxicity

FUS/TLS is a nucleic acid binding protein that, when mutated, can cause a subset of familial amyotrophic lateral sclerosis (fALS). Although FUS/TLS is normally located predominantly in the nucleus, the pathogenic mutant forms of FUS/TLS traffic to, and form inclusions in, the cytoplasm of affected s...

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Main Authors: Ju, Shulin, Tardiff, Daniel F., Han, Haesun, Divya, Kanneganti, Zhong, Quan, Maquat, Lynne E., Bosco, Daryl A., Hayward, Lawrence J., Brown, Robert H., Lindquist, Susan, Ringe, Dagmar, Petsko, Gregory A.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Public Library of Science 2011
Online Access:http://hdl.handle.net/1721.1/65580
https://orcid.org/0000-0003-1307-882X

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