Symptom Dimensions in OCD: Item-Level Factor Analysis and Heritability Estimates
To reduce the phenotypic heterogeneity of obsessive-compulsive disorder (OCD) for genetic, clinical and translational studies, numerous factor analyses of the Yale-Brown Obsessive Compulsive Scale checklist (YBOCS-CL) have been conducted. Results of these analyses have been inconsistent, likely as a...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Springer Science + Business Media B.V.
2011
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| Online Access: | http://hdl.handle.net/1721.1/65885 |
| _version_ | 1811091931550187520 |
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| author | Katerberg, Hilga Delucchi, Kevin L. Stewart, S. Evelyn Lochner, Christine Denys, Damiaan A. J. P. Stack, Denise E. Andresen, Joshua Michael Grant, J. E. Kim, Suck W. Williams, Kyle A. den Boer, Johan A. van Balkom, Anton J. L. M. Smit, Johannes H. van Oppen, Patricia Polman, Annemiek Jenike, Michael A. Stein, Dan J. Mathews, Carol A. Cath, Danielle C. |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Katerberg, Hilga Delucchi, Kevin L. Stewart, S. Evelyn Lochner, Christine Denys, Damiaan A. J. P. Stack, Denise E. Andresen, Joshua Michael Grant, J. E. Kim, Suck W. Williams, Kyle A. den Boer, Johan A. van Balkom, Anton J. L. M. Smit, Johannes H. van Oppen, Patricia Polman, Annemiek Jenike, Michael A. Stein, Dan J. Mathews, Carol A. Cath, Danielle C. |
| author_sort | Katerberg, Hilga |
| collection | MIT |
| description | To reduce the phenotypic heterogeneity of obsessive-compulsive disorder (OCD) for genetic, clinical and translational studies, numerous factor analyses of the Yale-Brown Obsessive Compulsive Scale checklist (YBOCS-CL) have been conducted. Results of these analyses have been inconsistent, likely as a consequence of small sample sizes and variable methodologies. Furthermore, data concerning the heritability of the factors are limited. Item and category-level factor analyses of YBOCS-CL items from 1224 OCD subjects were followed by heritability analyses in 52 OCD-affected multigenerational families. Item-level analyses indicated that a five factor model: (1) taboo, (2) contamination/cleaning, (3) doubts, (4) superstitions/rituals, and (5) symmetry/hoarding provided the best fit, followed by a one-factor solution. All 5 factors as well as the one-factor solution were found to be heritable. Bivariate analyses indicated that the taboo and doubts factor, and the contamination and symmetry/hoarding factor share genetic influences. Contamination and symmetry/hoarding show shared genetic variance with symptom severity. Nearly all factors showed shared environmental variance with each other and with symptom severity. These results support the utility of both OCD diagnosis and symptom dimensions in genetic research and clinical contexts. Both shared and unique genetic influences underlie susceptibility to OCD and its symptom dimensions. |
| first_indexed | 2024-09-23T15:10:13Z |
| format | Article |
| id | mit-1721.1/65885 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:10:13Z |
| publishDate | 2011 |
| publisher | Springer Science + Business Media B.V. |
| record_format | dspace |
| spelling | mit-1721.1/658852022-10-02T01:04:32Z Symptom Dimensions in OCD: Item-Level Factor Analysis and Heritability Estimates Katerberg, Hilga Delucchi, Kevin L. Stewart, S. Evelyn Lochner, Christine Denys, Damiaan A. J. P. Stack, Denise E. Andresen, Joshua Michael Grant, J. E. Kim, Suck W. Williams, Kyle A. den Boer, Johan A. van Balkom, Anton J. L. M. Smit, Johannes H. van Oppen, Patricia Polman, Annemiek Jenike, Michael A. Stein, Dan J. Mathews, Carol A. Cath, Danielle C. Massachusetts Institute of Technology. Department of Chemical Engineering Andresen, Joshua Michael Andresen, Joshua Michael To reduce the phenotypic heterogeneity of obsessive-compulsive disorder (OCD) for genetic, clinical and translational studies, numerous factor analyses of the Yale-Brown Obsessive Compulsive Scale checklist (YBOCS-CL) have been conducted. Results of these analyses have been inconsistent, likely as a consequence of small sample sizes and variable methodologies. Furthermore, data concerning the heritability of the factors are limited. Item and category-level factor analyses of YBOCS-CL items from 1224 OCD subjects were followed by heritability analyses in 52 OCD-affected multigenerational families. Item-level analyses indicated that a five factor model: (1) taboo, (2) contamination/cleaning, (3) doubts, (4) superstitions/rituals, and (5) symmetry/hoarding provided the best fit, followed by a one-factor solution. All 5 factors as well as the one-factor solution were found to be heritable. Bivariate analyses indicated that the taboo and doubts factor, and the contamination and symmetry/hoarding factor share genetic influences. Contamination and symmetry/hoarding show shared genetic variance with symptom severity. Nearly all factors showed shared environmental variance with each other and with symptom severity. These results support the utility of both OCD diagnosis and symptom dimensions in genetic research and clinical contexts. Both shared and unique genetic influences underlie susceptibility to OCD and its symptom dimensions. Obsessive Compulsive Foundation Tourette Syndrome Association Anxiety Disorders Association of America American Academy of Child and Adolescent Psychiatry 2011-09-19T14:26:34Z 2011-09-19T14:26:34Z 2010-04 2009-05 Article http://purl.org/eprint/type/JournalArticle 0001-8244 1573-3297 http://hdl.handle.net/1721.1/65885 Katerberg, Hilga et al. “Symptom Dimensions in OCD: Item-Level Factor Analysis and Heritability Estimates.” Behavior Genetics 40 (2010): 505-517. en_US http://dx.doi.org/10.1007/s10519-010-9339-z Behavior Genetics Creative Commons Attribution Noncommercial License http://creativecommons.org/licenses/by-nc/2.5 application/pdf Springer Science + Business Media B.V. Springer |
| spellingShingle | Katerberg, Hilga Delucchi, Kevin L. Stewart, S. Evelyn Lochner, Christine Denys, Damiaan A. J. P. Stack, Denise E. Andresen, Joshua Michael Grant, J. E. Kim, Suck W. Williams, Kyle A. den Boer, Johan A. van Balkom, Anton J. L. M. Smit, Johannes H. van Oppen, Patricia Polman, Annemiek Jenike, Michael A. Stein, Dan J. Mathews, Carol A. Cath, Danielle C. Symptom Dimensions in OCD: Item-Level Factor Analysis and Heritability Estimates |
| title | Symptom Dimensions in OCD: Item-Level Factor Analysis and Heritability Estimates |
| title_full | Symptom Dimensions in OCD: Item-Level Factor Analysis and Heritability Estimates |
| title_fullStr | Symptom Dimensions in OCD: Item-Level Factor Analysis and Heritability Estimates |
| title_full_unstemmed | Symptom Dimensions in OCD: Item-Level Factor Analysis and Heritability Estimates |
| title_short | Symptom Dimensions in OCD: Item-Level Factor Analysis and Heritability Estimates |
| title_sort | symptom dimensions in ocd item level factor analysis and heritability estimates |
| url | http://hdl.handle.net/1721.1/65885 |
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