The Cycad Genotoxin MAM Modulates Brain Cellular Pathways Involved in Neurodegenerative Disease and Cancer in a DNA Damage-Linked Manner
Methylazoxymethanol (MAM), the genotoxic metabolite of the cycad azoxyglucoside cycasin, induces genetic alterations in bacteria, yeast, plants, insects and mammalian cells, but adult nerve cells are thought to be unaffected. We show that the brains of adult C57BL6 wild-type mice treated with a sing...
Main Authors: | Kisby, Glen E., Fry, Rebecca C., Lasarev, Michael R., Bammler, Theodor K., Beyer, Richard P., Churchwell, Mona, Doerge, Daniel R., Meira, Lisiane B., Palmer, Valerie S., Ramos-Crawford, Ana-Luiza, Ren, Xuefeng, Sullivan, Robert C., Kavanagh, Terrance J., Samson, Leona D., Zarbl, Helmut, Spencer, Peter S. |
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Other Authors: | Massachusetts Institute of Technology. Center for Environmental Health Sciences |
Format: | Article |
Language: | en_US |
Published: |
Public Library of Science
2011
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Online Access: | http://hdl.handle.net/1721.1/65888 https://orcid.org/0000-0002-7112-1454 |
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