Divergent Pathways in the Biosynthesis of Bisindole Natural Products
Two molecules of the amino acid L-tryptophan are the biosynthetic precursors to a class of natural products named the “bisindoles.” Hundreds of these bisindole molecules have been isolated from natural sources, and many of these molecules have potent medicinal properties. Recent studies have clarifi...
| Main Authors: | , |
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| Format: | Article |
| Language: | en_US |
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Elsevier
2011
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| Online Access: | http://hdl.handle.net/1721.1/65908 https://orcid.org/0000-0001-5486-2755 |
| _version_ | 1811080518718980096 |
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| author | Ryan, Katherine S. Drennan, Catherine L |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Ryan, Katherine S. Drennan, Catherine L |
| author_sort | Ryan, Katherine S. |
| collection | MIT |
| description | Two molecules of the amino acid L-tryptophan are the biosynthetic precursors to a class of natural products named the “bisindoles.” Hundreds of these bisindole molecules have been isolated from natural sources, and many of these molecules have potent medicinal properties. Recent studies have clarified the biosynthetic construction of six bisindole molecules, revealing novel enzymatic mechanisms and leading to combinatorial synthesis of new bisindole compounds. Collectively, these results provide a vantage point for understanding how much of the diversity of the bisindole class is generated from a small number of diverging pathways from L-tryptophan, as well as enabling identification of bisindoles that are likely derived via completely distinct biosynthetic pathways. |
| first_indexed | 2024-09-23T11:32:59Z |
| format | Article |
| id | mit-1721.1/65908 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:32:59Z |
| publishDate | 2011 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/659082022-09-27T20:16:38Z Divergent Pathways in the Biosynthesis of Bisindole Natural Products Ryan, Katherine S. Drennan, Catherine L Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Chemistry Drennan, Catherine L. Ryan, Katherine S. Drennan, Catherine L. Two molecules of the amino acid L-tryptophan are the biosynthetic precursors to a class of natural products named the “bisindoles.” Hundreds of these bisindole molecules have been isolated from natural sources, and many of these molecules have potent medicinal properties. Recent studies have clarified the biosynthetic construction of six bisindole molecules, revealing novel enzymatic mechanisms and leading to combinatorial synthesis of new bisindole compounds. Collectively, these results provide a vantage point for understanding how much of the diversity of the bisindole class is generated from a small number of diverging pathways from L-tryptophan, as well as enabling identification of bisindoles that are likely derived via completely distinct biosynthetic pathways. Howard Hughes Predoctoral Fellowship National Institutes of Health (U.S.) (grant GM65337) 2011-09-21T17:41:49Z 2011-09-21T17:41:49Z 2009-04 Article http://purl.org/eprint/type/JournalArticle http://hdl.handle.net/1721.1/65908 Ryan, Katherine S., and Catherine L. Drennan. “Divergent Pathways in the Biosynthesis of Bisindole Natural Products.” Chemistry & Biology 16.4 (2009) : 351-364. https://orcid.org/0000-0001-5486-2755 en_US http://dx.doi.org/10.1016/j.chembiol.2009.01.017 Chemistry and Biology Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Elsevier Prof. Drennan via Erja Kajosalo |
| spellingShingle | Ryan, Katherine S. Drennan, Catherine L Divergent Pathways in the Biosynthesis of Bisindole Natural Products |
| title | Divergent Pathways in the Biosynthesis of Bisindole Natural Products |
| title_full | Divergent Pathways in the Biosynthesis of Bisindole Natural Products |
| title_fullStr | Divergent Pathways in the Biosynthesis of Bisindole Natural Products |
| title_full_unstemmed | Divergent Pathways in the Biosynthesis of Bisindole Natural Products |
| title_short | Divergent Pathways in the Biosynthesis of Bisindole Natural Products |
| title_sort | divergent pathways in the biosynthesis of bisindole natural products |
| url | http://hdl.handle.net/1721.1/65908 https://orcid.org/0000-0001-5486-2755 |
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