A malaria diagnostic system based on electric impedance spectroscopy
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2011.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2011
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| Online Access: | http://hdl.handle.net/1721.1/66030 |
| _version_ | 1826206837500805120 |
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| author | Ha, Sungjae |
| author2 | Anantha P. Chandrakasan. |
| author_facet | Anantha P. Chandrakasan. Ha, Sungjae |
| author_sort | Ha, Sungjae |
| collection | MIT |
| description | Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2011. |
| first_indexed | 2024-09-23T13:39:02Z |
| format | Thesis |
| id | mit-1721.1/66030 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T13:39:02Z |
| publishDate | 2011 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/660302019-04-10T10:37:19Z A malaria diagnostic system based on electric impedance spectroscopy Ha, Sungjae Anantha P. Chandrakasan. Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science. Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science. Electrical Engineering and Computer Science. Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2011. Cataloged from PDF version of thesis. Includes bibliographical references (p. 69-71). Malaria caused by Plasmodium falciparum infection is one of the major threats to world health and especially to the community without proper medical care. New approach to cost-efficient, portable, miniaturized diagnostic kit is needed. This work explores electric impedance spectroscopy (EIS) on a microfluidic device as a means of malaria diagnosis. This work introduces a microfabricated probe with microfluidic channel, and a high speed impedance analyzer circuit board. Combination of microfluidic device and circuit board resulted in a small-sized EIS system for micro-particles such as human red blood cell (RBC). After invasion by the parasites, RBC undergoes physiological changes including electrical property of cytoplasm and membrane. Detection of infected RBC is demonstrated as well as differentiation of micro-beads by surface charge density using EIS-based diagnostic system. Diagnosis based on EIS has merits over other diagnostic methods since it is label-free and quantitative test and applicable to whole blood, and also the test does not need bulky optical and electrical equipments. by Sungjae Ha. S.M. 2011-09-27T18:34:29Z 2011-09-27T18:34:29Z 2011 2011 Thesis http://hdl.handle.net/1721.1/66030 752144506 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 71 p. application/pdf Massachusetts Institute of Technology |
| spellingShingle | Electrical Engineering and Computer Science. Ha, Sungjae A malaria diagnostic system based on electric impedance spectroscopy |
| title | A malaria diagnostic system based on electric impedance spectroscopy |
| title_full | A malaria diagnostic system based on electric impedance spectroscopy |
| title_fullStr | A malaria diagnostic system based on electric impedance spectroscopy |
| title_full_unstemmed | A malaria diagnostic system based on electric impedance spectroscopy |
| title_short | A malaria diagnostic system based on electric impedance spectroscopy |
| title_sort | malaria diagnostic system based on electric impedance spectroscopy |
| topic | Electrical Engineering and Computer Science. |
| url | http://hdl.handle.net/1721.1/66030 |
| work_keys_str_mv | AT hasungjae amalariadiagnosticsystembasedonelectricimpedancespectroscopy AT hasungjae malariadiagnosticsystembasedonelectricimpedancespectroscopy |