Process management applications in biopharmaceutical drug production
Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Engineering Systems Division; in conjunction with the Leaders for Global Operations Program at MIT, 2011.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2011
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| Online Access: | http://hdl.handle.net/1721.1/66048 |
| _version_ | 1826204330618781696 |
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| author | Smith, Stephen E |
| author2 | Charles Cooney and Steven Spear. |
| author_facet | Charles Cooney and Steven Spear. Smith, Stephen E |
| author_sort | Smith, Stephen E |
| collection | MIT |
| description | Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Engineering Systems Division; in conjunction with the Leaders for Global Operations Program at MIT, 2011. |
| first_indexed | 2024-09-23T12:52:53Z |
| format | Thesis |
| id | mit-1721.1/66048 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T12:52:53Z |
| publishDate | 2011 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/660482022-01-28T14:53:40Z Process management applications in biopharmaceutical drug production Smith, Stephen E Charles Cooney and Steven Spear. Leaders for Global Operations Program. Leaders for Global Operations Program at MIT Massachusetts Institute of Technology. Engineering Systems Division Sloan School of Management Sloan School of Management. Engineering Systems Division. Leaders for Global Operations Program. Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Engineering Systems Division; in conjunction with the Leaders for Global Operations Program at MIT, 2011. Cataloged from PDF version of thesis. Includes bibliographical references (p. 71-73). Genzyme's manufacturing and supply chain organization is responsible for the production and delivery of medically necessary medicines for patients with rare diseases around the world. Because of the nature of the products produced at Genzyme, a lapse in operational performance has societal as well as economic impacts. Therefore increased understanding of the complex production systems at Genzyme is helpful to reduce risk and improve performance. This thesis is an analysis of a system of two critical production processes at Genzyme. These processes are studied collectively because shared resources make them a tightly coupled system. The research is presented in three sections. The first section explores the current state of the system and explains general performance trends. The second section examines the impact of scheduling complexity arising from shared resources. The third section discusses how process improvement methodologies could be applied at Genzyme. The following conclusions arise from the work conducted for this thesis. First, the performance of the system has declined due to an increase in utilization and an already high level of variability. Second, variability caused by shared resource conflicts can be minimized using new scheduling techniques. And finally, continuous improvement methods are recommended to further reduce variability and increase overall process performance. by Stephen Smith. S.M. M.B.A. 2011-09-27T18:36:40Z 2011-09-27T18:36:40Z 2011 2011 Thesis http://hdl.handle.net/1721.1/66048 752305381 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 73 p. application/pdf Massachusetts Institute of Technology |
| spellingShingle | Sloan School of Management. Engineering Systems Division. Leaders for Global Operations Program. Smith, Stephen E Process management applications in biopharmaceutical drug production |
| title | Process management applications in biopharmaceutical drug production |
| title_full | Process management applications in biopharmaceutical drug production |
| title_fullStr | Process management applications in biopharmaceutical drug production |
| title_full_unstemmed | Process management applications in biopharmaceutical drug production |
| title_short | Process management applications in biopharmaceutical drug production |
| title_sort | process management applications in biopharmaceutical drug production |
| topic | Sloan School of Management. Engineering Systems Division. Leaders for Global Operations Program. |
| url | http://hdl.handle.net/1721.1/66048 |
| work_keys_str_mv | AT smithstephene processmanagementapplicationsinbiopharmaceuticaldrugproduction |