Feature-based investment cost estimation based on modular design of a continuous pharmaceutical manufacturing system
Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering; in conjunction with the Leaders for Global Operations Program at MIT, June 2011.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2011
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| Online Access: | http://hdl.handle.net/1721.1/66063 |
| _version_ | 1811092029257547776 |
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| author | Collins, Donovan (Donovan Scott) |
| author2 | Bernhardt Trout and Charlie Fine. |
| author_facet | Bernhardt Trout and Charlie Fine. Collins, Donovan (Donovan Scott) |
| author_sort | Collins, Donovan (Donovan Scott) |
| collection | MIT |
| description | Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering; in conjunction with the Leaders for Global Operations Program at MIT, June 2011. |
| first_indexed | 2024-09-23T15:11:47Z |
| format | Thesis |
| id | mit-1721.1/66063 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T15:11:47Z |
| publishDate | 2011 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/660632022-01-27T21:32:13Z Feature-based investment cost estimation based on modular design of a continuous pharmaceutical manufacturing system Collins, Donovan (Donovan Scott) Bernhardt Trout and Charlie Fine. Leaders for Global Operations Program. Leaders for Global Operations Program at MIT Massachusetts Institute of Technology. Department of Chemical Engineering Sloan School of Management Sloan School of Management. Chemical Engineering. Leaders for Global Operations Program. Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering; in conjunction with the Leaders for Global Operations Program at MIT, June 2011. "June 2011." Cataloged from PDF version of thesis. Includes bibliographical references (p. 72-73). Previous studies of continuous manufacturing processes have used equipment-factored cost estimation methods to predict savings in initial plant investment costs. In order to challenge and validate the existing methods of cost estimation, feature-based cost estimates were constructed based on a modular process design model. Synthesis of an existing chemical intermediate was selected as the model continuous process. A continuous process was designed that was a literal, step by step, translation of the batch process. Supporting design work included process flow diagrams and basic piping and instrumentation diagrams. Design parameters from the process model were combined with feature-based costs to develop a series of segmented cost estimates for the model continuous plant at several production scales. Based on this analysis, the continuous facility seems to be intrinsically less expensive only at a relatively high production scale. Additionally, the distribution of cost areas for the continuous facility differs significantly from the distribution previous assumed for batch plants. This finding suggests that current models may not be appropriate for generating cost estimates for continuous plants. These results should not have a significant negative impact on the value proposition for the continuous manufacturing platform. The continuous process designed for this project was not optimized. Therefore, this work reiterates that the switch to continuous must be accompanied with optimization and innovation in the underlying continuous chemistry. by Donovan Collins. S.M. M.B.A. 2011-09-27T18:38:29Z 2011-09-27T18:38:29Z 2011 Thesis http://hdl.handle.net/1721.1/66063 753704109 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 73 p. application/pdf Massachusetts Institute of Technology |
| spellingShingle | Sloan School of Management. Chemical Engineering. Leaders for Global Operations Program. Collins, Donovan (Donovan Scott) Feature-based investment cost estimation based on modular design of a continuous pharmaceutical manufacturing system |
| title | Feature-based investment cost estimation based on modular design of a continuous pharmaceutical manufacturing system |
| title_full | Feature-based investment cost estimation based on modular design of a continuous pharmaceutical manufacturing system |
| title_fullStr | Feature-based investment cost estimation based on modular design of a continuous pharmaceutical manufacturing system |
| title_full_unstemmed | Feature-based investment cost estimation based on modular design of a continuous pharmaceutical manufacturing system |
| title_short | Feature-based investment cost estimation based on modular design of a continuous pharmaceutical manufacturing system |
| title_sort | feature based investment cost estimation based on modular design of a continuous pharmaceutical manufacturing system |
| topic | Sloan School of Management. Chemical Engineering. Leaders for Global Operations Program. |
| url | http://hdl.handle.net/1721.1/66063 |
| work_keys_str_mv | AT collinsdonovandonovanscott featurebasedinvestmentcostestimationbasedonmodulardesignofacontinuouspharmaceuticalmanufacturingsystem |